151038-94-7, 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Acetoxycisplatin(4-acetylphenyl)carbamate (215 mg, 0.400 mmol, 1 .0 equiv) was dissolved in DMF (0.05M, 8 mL) and treated with 6-(2,5-dioxo-2,5-dihydro-1 H- pyrrol-1 -yl)hexanehydrazide TFA salt (163 mg, 0.480 mmol, 1 .2 equiv) at room temprature. The reaction mixture was stirred at room temperature overnight. Dichloromethane was added to the reaction mixture and the suspension was filtered to provide a yellow solid (230mg, 77% yield, 90.9% pure). The residue obtained was triturated with MeCN to provide compound 18 as a yellow solid (144 mg, 48% yield, 97.3% pure). 1H NMR (500 MHz, DMF-d7) delta 10.28 (s, 0.4H), 10.15 (s, 0.6H), 9.74 (brs, 1 H), 7.79-7.72 (m, 2H), 7.61 -7.54 (m, 2H), 7.22-6.81 (m, 6H), 7.02 (s, 2H), 3.50-3.44 (m, 2H), 2.74-2.70 (m, 1 .2H), 2.40-2.35 ( m, 0.8H), 2.33 (s, 2H), 2.29 (s, 1 H), 1 .93 (s, 3H), 1 .72-1 .63 (m, 2H), 1 .62-1 .53 (m, 2H), 1 .42-1 .29 (m, 2H); HPLC-MS 97%, m/z for CziHsoC NeOyPt [(M+H)+] = 745.2., 151038-94-7
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Reference£º
Patent; BLEND THERAPEUTICS, INC.; MOREAU, Benoit; BILODEAU, Mark T.; WHALEN, Kerry; MEETZE, Kristan; SINGH, Sukhjeet; WOOSTER, Richard; LEMELIN, Charles-Andre; (139 pag.)WO2015/200250; (2015); A1;,
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