872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2
General procedure: 4-Chloro-benzenesulfonyl chloride (6.33 g, 30 mmol) was added to a solution of 4-dimethylaminopyridine (DMAP) (3.67 g, 30 mmol) in anhydrous DMF (25 mL) at 0 ¡ãC. The reaction was stirred at 23¡ã C for 30 minutes. A solution of 2-methyl-l-pyrroline (2.08 g, 25 mmol) in anhydrous DMF (25 mL) was added and the reaction was stirred at the same temperature for 1 hour. Methanesulfonic acid (4.87 mL, 75 mmol) was added to the reaction at 0 ¡ãC. The reaction was then stirred at 23¡ã C for 2 hours. 4-Bromo-2-fluoro-phenyl hydrazine hydrochloride (9.06 g, 35.7 mmol) was added and stirred for an additional hour at 23¡ã C. The reaction was then heated to 85 ¡ãC for 12 hours in a sealed tube. The reaction was then cooled to room temperature and concentrated in vacuo. The resulting residue was dissolved in ethyl acetate and washed with saturated aqueous solution of NaHC03 followed by brine. The combined organic layers were dried over anhydrous Na2S04; filtered and concentrated in vacuo to give a crude product, which was purified by column (0241) chromatography on silica gel eluting with 70:30 Hex: EtOAc to give N-(2-(5-bromo-7-fluoro- 2-methyl-lH-indol-3-yl)ethyl)-4-chlorobenzenesulfonamide (SI) as an off-white solid
The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; WANG, Xiang; BARBOUR, Patrick; (44 pag.)WO2016/176634; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem