Recommanded Product: 7423-55-4, Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 7423-55-4, Name is 3-Maleimidopropionic acid, SMILES is C1(N(C(C=C1)=O)CCC(=O)O)=O, belongs to pyrrolines compound. In a article, author is Kaloglu, Murat, introduce new discover of the category.
Palladium-PEPPSI-NHC Complexes Bearing Imidazolidin-2-Ylidene Ligand: Efficient Precatalysts for the Direct C5-Arylation of N-Methylpyrrole-2-Carboxaldehyde
The Pd-catalyzed direct arylation of pyrroles is an important research field for organic synthesis and catalysis chemistry. However, imidazolidin-2-ylidene based Pd-NHC complexes (NHC=N-heterocyclic carbene) have not yet been employed as catalysts for the direct C5 mono-arylation of C2-substituted N-methylpyrrole derivatives with aryl halides. Therefore, we now report the synthesis and characterization of new 1,3-bis(substituted benzyl) imidazolinium salts as carbene precursors, and their corresponding Pd-PEPPSI-NHC type complexes (PEPPSI=Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation). The catalytic properties of these complexes have been evaluated in the direct C5 mono-arylation of N-methylpyrrole-2-carboxaldehyde with a wide variety of (hetero)aryl halides. This environmentally attractive procedure has also been found to be tolerant to a wide variety of functional groups on the aryl halides such as formyl, acetyl, nitrile, fluoro or trifluoromethyl, and good yields have been obtained in presence of 1 mol% catalyst loading at 120 degrees C. [GRAPHICS] .
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem