With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.
5264-35-7, (f) Ethyl 5-bromo-6-chloro-2-[(2-oxopyrrolidin-l-yl)methyl]nicotinateEthyl 5-bromo-2-(broniomethyl)-6-chloronicotinate (395 mg, 1.11 mmol) was added to a solution of 2-methoxy-l-pyrroline (329 mg, 3.32 mmol) in iV-methyl-2-pyrrolidone (8 mL). The reaction was heated in the micro wave at 80 0C for 60 min, water was added and o the solid material was filtered, washed and dried to give ethyl 5-bromo-6-chloro-2-[(2- oxopyrrolidin-l-yl)methyl]nicotinate. Yield: 360 mg (90percent).1H-NMR (500 MHz, CDCl3) delta 1.42-1.45 (3H, m), 2.10-2.20 (2H, m), 2.48-2.55 (2H, m), 3.52-3.61 (2H, m), 4.40-4.47 (2H, m), 4.91 (2H, s), 8.46 (IH, s).
5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; WO2008/85119; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem