Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge.1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, belongs to pyrrolines compound, is a common compound. In a patnet, author is Li, Zhenghua, once mentioned the new application about 1977-07-7, Product Details of 1977-07-7.
Enantioselective Cyanoborylation of Allenes by N-Heterocyclic Carbene-Copper Catalysts
The simultaneous incorporation of both a cyano group and a boryl unit into the C=C double bonds of allenes in a regio- and stereoselective fashion is of much interest and importance but remains a significant challenge. We report herein a copper-catalyzed chemo-, regio-, and enantioselective cyanoborylation of allenes, which afforded a family of valuable enantiopure beta-boryl allyl nitriles. The high enantioselectivity was achieved by installing of appropriate substituents at the C2 and C6 positions of the naphthyl groups in our newly synthesized N-heterocyclic carbene (NHC) ligands. The reaction mechanism has been clarified by some stoichiometric reactions and computational studies. This work provides an inspiring example of the development of selective catalytic reactions for the synthesis of functional molecules through fine-tuning the ligands in catalysis.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 1977-07-7. Product Details of 1977-07-7.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem