Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Organic & Biomolecular Chemistry called Synthesis of N-alkylated 2-pyridones through Pummerer type reactions of activated sulfoxides and 2-fluoropyridine derivatives, Author is Hu, Gang; Xu, Jiaxi; Li, Pingfan, the main research direction is pyridone alkylated preparation Pummerer sulfoxide fluoropyridine.Computed Properties of C5H3ClFN.
N-Alkylated 2-pyridone products were obtained in good to excellent yields through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride activated sulfoxides and 2-fluoropyridine derivatives, followed by hydrolysis. This is a rare case that uses 2-fluoropyridine as a nucleophile in Pummerer type reactions.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem