Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Chiral, biomimetic total synthesis of (-)-aplysistatin. Author is Shieh, Hong Ming; Prestwich, Glenn D..
The marine antineoplastic agent aplysistatin (I), from Aplysia angasi, was prepared enantiospecifically in 6 steps from R-(+)-malic acid. The key step was the biomimetic cyclization of lactone II with 2,4,4,6-tetrabromocyclohexa-2,5-dienone in MeNO2 at 20° for 2 h to give a 19:81 mixture of dihydroaplysistatins III (β-Br, β-Me, α-H; α-Br, α-Me, β-H).
In some applications, this compound(58081-05-3)Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem