The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride(SMILESS: O=S(C1=CC2=C(N(C(C3CC3)=O)CC2)C=C1)(Cl)=O,cas:879562-21-7) is researched.Quality Control of Ethyl oxazole-5-carboxylate. The article 《Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:879562-21-7).
NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.
Here is just a brief introduction to this compound(879562-21-7)Recommanded Product: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, more information about the compound(1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride) is in the article, you can click the link below.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem