In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A novel synthesis of (R)- and (S)-4-hydroxytetrahydrofuran-2-ones, published in 1987-06-30, which mentions a compound: 58081-05-3, mainly applied to furanone hydro hydroxy chiral; hydroxy lactone chiral; butanolide hydroxy chiral; dioxolaneacetate methyl; dioxaspirodecaneacetate chiral; spirodioxadecaneacetate chiral, SDS of cas: 58081-05-3.
The hydroxy ester I (R = H, R1 = OH), prepared from L-ascorbic acid by sequential treatment with acetone and AcCl, 30% H2O2 and CaCO3, and Me2SO4, was treated with MeSO2Cl and pyridine in CH2Cl2 to give 90% I (R = H, R1 = MeSO3), which, when heated at 85° with LiCl in DMF furnished a mixture of the erythro and threo chloro esters I (R = Cl, R1 = H; R = H, R1 = Cl) (II). Upon hydrogenolysis with 10% Pd/C in the presence of Et3N, II yielded the ester I (R = R1 = H), which was treated with dilute HCl giving a nearly quant. yield of hydroxylactone III. The (S)-enantiomer was analogously prepd from D-isoascorbic acid.
Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)SDS of cas: 58081-05-3 require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem