Ishibashi, Fumito; Hayashita, Mami; Okazaki, Momotoshi; Shuto, Yoshihiro published the article 《Improved procedure for the enantiomeric synthesis of 1-hydroxy/acetoxy-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans: total syntheses of (+)-paulownin, (+)-phrymarin I and (+)-phrymarin II》. Keywords: lignan paulownin phrymarin enantiomeric synthesis photocyclization.They researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Electric Literature of C4H6O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:58081-05-3) here.
Short enantiomeric syntheses of the 1-hydroxy/acetoxy-3,7-dioxabicyclo[3.3.0]octane lignans, (+)-paulownin (I, R1 = R2 = R3 = H), and (+)-phrymarin I (I, R1 = R2 = OMe, R3 = Ac) and II (I, R1 = OMe, R2 = H, R3 = Ac), were accomplished by starting from the chiral synthon, (R)-(+)-3-hydroxybutanolide, and employing photocyclization as the key step.
Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Electric Literature of C4H6O3 require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem