Lei, Jie; Li, Yong; Xu, Jia; Tang, Dian-Yong; Shao, Jing-Wei; Li, Hong-yu; Chen, Zhong-Zhu; Xu, Zhi-Gang published the article 《An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water》. Keywords: amine isocyanide chromone carboxaldehyde formic acid Ugi type addition; alkylaminomethylene oxochromane carboxamide preparation diastereoselective chemoselective green chem.They researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Name: 4-Methoxypiperidine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4045-24-3) here.
A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. The hydrogen bond can dictate the stereo-outcome of olefins and provided an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.
Different reactions of this compound(4-Methoxypiperidine)Name: 4-Methoxypiperidine require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem