55750-49-7, Ethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55750-49-7, To a solution of 1-((tert-butoxycarbonyl)amino)-2-aminoethane (42)23 26, 27 (1.13 g, 7.1 minol) in saturated NaHCO3 (35 mL) at 0 C was added N-(ethoxycarbonyl)maleimide22 (45) (1.1 g, 7.1 minol). The reaction mixture was warmed to rt and stirred for 15 min.THF (55 mL) was then added and the reaction mixture stirred for a further 45 mi H20 (50 mL) was added and the aqueous phase extracted with EtOAc (3 x 75 mL). The combined organic extracts were washed with saturated NaCI (100 mL) and dried over Mg504. Removal of the solvent in vacuo gave an off-white solid that was purified by flash chromatography (0%, then 5%, then 10% EtOAc in CH2CI2) to yleld the title compound 46(1.1 g 58%) as a white solid. Mp. 126-128 C; Rf(10% EtOAc in CH2CI2) 0.28; IR (ATR)vmaxjcm1 3350 (C-H), 3089 (C-H), 2977, 1701 (C=O), 1678 (C=O), 1516, 1434, 1288,1256, 1167, 944, 844, 692, 623; 1H NMR (400 MHz, CDCI3) oe 1.40 (9H, 5), 3.30-3.35 (2H,m), 3.66 (2H, t, J = 6.0 Hz), 4.74 (1H, br 5), 6.71 (2H, 5); 13C NMR (100 MHz, CDCI3) oe28.3, 38.0, 39.4, 79.5, 131.1, 155.9, 170.8. The 1H and 13C NMR data obtained was in agreement with that reported from literature.23
As the paragraph descriping shows that 55750-49-7 is playing an increasingly important role.
Reference£º
Patent; SAMMUT, Ivan Andrew; HARRISON, Joanne Clare; HEWITT, Russell James; READ, Morgayn Iona; STANLEY, Nathan John; WOODS, Laura Molly; KUEH, Jui Thiang Brian; JAY-SMITH, Morgan; SMITH, Robin Andrew James; GILES, Gregory; LARSEN, Lesley; RENNISON, David; BRIMBLE, Margaret Anne; LARSEN, David Samuel; (209 pag.)WO2017/95237; (2017); A1;,
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