5264-35-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO. In a Article, authors is Shmatova, Olga I.£¬once mentioned of 5264-35-7
Highly beta-regioselective Friedel-Crafts aminoalkylation of pyrroles with cyclic perfluoroalkylated imines
A Friedel-Crafts-type alkylation reaction was studied between various pyrroles and alpha-polyfluoroalkylated cyclic imines that were activated by Lewis acids. The reaction proceeded under mild conditions and provided a high yielding synthesis of alpha-CF3-substituted pyrrolidines and piperidines as well as seven-membered analogues that contained a pyrrole ring. The unpredictably high beta-selectivity for the aminoalkylation of both 1H-pyrrole and N-substituted pyrrole was observed as a result of a thermodynamically-controlled electrophilic substitution reaction. The computational data are in full agreement with the experimental results, which confirmed the observed regioselectivity as a result of the lower energy of the beta-substituted pyrroles that contain alpha-trifluoromethyl-substituted pyrrolidine, piperidine, and azepane rings. Trifluoromethyl-substituted cyclic imines were activated by various Lewis acids and underwent a reaction with pyrrole derivatives. An unpredictable beta-selectivity was observed. The regioselectivity of the aminoalkylation was explained by computation data, which also confirmed the isomerization of the alpha isomer into the beta isomer. Copyright
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.5264-35-7. In my other articles, you can also check out more blogs about 5264-35-7
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem