Category: 1036847-90-1

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 1036847-90-1, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1036847-90-1

Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy

CPT-11 is a clinically used cancer drug, and it is a prodrug of the potent topoisomerase I inhibitor, SN-38 (7-ethyl-10-hydroxycamptothecin). To bypass the need for the in vivo conversion of CPT-11 and increase the therapeutic index, bifunctional derivatives of SN-38 were prepared for use in antibody-based targeted therapy of cancer. The general synthetic scheme incorporated an acetylene-azide click cycloaddition step in the design, a short polyethylene glycol spacer for aqueous solubility, and a maleimide group for conjugation. Conjugates of a humanized anti-CEACAM5 monoclonal antibody, hMN-14, prepared using these SN-38 derivatives were evaluated in vitro for stability in buffer and human serum and for antigen-binding and cytotoxicity in a human colon adenocarcinoma cell line. Conjugates of hMN-14 and SN-38 derivatives 16 and 17 were found promising for further development.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Related Products of 1036847-90-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1036847-90-1, Name is 4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-(prop-2-yn-1-yl)cyclohexanecarboxamide, molecular formula is C15H18N2O3. In a article£¬once mentioned of 1036847-90-1

NEOADJUVANT USE OF ANTIBODY-DRUG CONJUGATES

The present invention concerns improved methods and compositions for neoadjuvant use of antibody-drug conjugates (ADCs) in cancer therapy, preferably ADCs comprising an anthracycline or camptothecin, more preferably SN-38 or pro-2-pyrrolinodoxorubicin (P2PDox). The ADC is administered as a neoadjuvant, prior to treatment with a standard anti-cancer therapy such as surgery, radiation therapy, chemotherapy, or immunotherapy. Neoadjuvant use of the ADC substantially improves the efficacy of standard anti-cancer therapy and may debulk a primary tumor or eliminate micrometasteses. In most preferred embodiments, neoadjuvant ADC in combination with a standard anti-cancer therapy is successful in treating cancers that are resistant to standard treatments, such as triple-negative breast cancer (TNBC).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1036847-90-1

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Application of 1036847-90-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1036847-90-1, Name is 4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-(prop-2-yn-1-yl)cyclohexanecarboxamide, molecular formula is C15H18N2O3. In a Patent£¬once mentioned of 1036847-90-1

Hydrophilic carbonate type antibody coupling drug (by machine translation)

The hydrophilic carbonate type antibody drug conjugate or the pharmaceutically acceptable salt, of the hydrophilic carbonate type antibody drug conjugate provided by the invention or a pharmaceutically acceptable salt, thereof can effectively release the drug, in a tumor weak acid microenvironment to obtain a better in-vivo drug effect, for tumors, and can obtain a good body DAR at a high PK. (by machine translation)

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Related Products of 1036847-90-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1036847-90-1, Name is 4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-(prop-2-yn-1-yl)cyclohexanecarboxamide, molecular formula is C15H18N2O3. In a Patent£¬once mentioned of 1036847-90-1

With two different antibody drug conjugates (by machine translation)

The invention discloses a with two different antibody drug conjugates, the invention will be a medicament in order to fixed-point coupling mode is connected to the antibody on the cysteine residue, and a 2nd different mechanisms of cytotoxic drugs in order to non-fixed point coupled mode is connected to the antibody on the cysteine residues. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1036847-90-1

Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem