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NAPHTHALIMIDE-BISINDOLYMALEIMIDE DYE COMPOUND AND DYE COMPOSITION COMPRISING THE COMPOUND

The present invention refers to compounds and is excellent in fluorescent properties including relates dye composition comprising. (by machine translation)

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Related Products of 1122-10-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1122-10-7, molcular formula is C4HBr2NO2, introducing its new discovery.

Total syntheses of the slime mold alkaloid arcyriacyanin A

Arcyriacyanin A (1) has been synthesized by three different routes. In the first synthesis the bisbromomagnesium salt of 2,4′-biindole (5) was treated with dibromomaleimide (6) to yield arcyriacyanin A (1). The second approach used an intramolecular Hock reaction for the cyclization of a 4-(triflyloxy)arcyriarubin 8 to N-methylarcyriacyanin A (2). Thirdly, compound 2 was obtained by a domino Heck reaction between 3-bromo-4-[1(tert-butoxycarbonyl)indol-3-yl]-1-methylmaleimide (9) and 4-bromoindole (10). The N-methyl derivative 2 could be transformed into arcyriacyanin A (1) by standard methods.

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Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues

The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2?-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.

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Chemically-Locked Bispecific Antibodies

There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.

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Solvent dependent energy transfer of N-bridged naphthalimide- bisindolymaleimide fluorescent dyes

Double build-in chromophores, naphthalimide (NIM) and bisindolymaleimide (BIM), were synthesized and characterized. Absorption and emission properties of double chromophores dye were fully investigated in various solvents. The priority of through bond energy transfer (TBET) to NTM or BIM is solvent dependent. There appears large different emission wavelength change in CHCl 3 and DMF with alkyl attached to BIM. However, the product of cyclohexyl substitution leads to a different emission behavior, which is non-sensitivity to solvent polarity. Quantum chemical calculation for the molecular orbital reveals that intramolecular charge transfer (ICT) is the key factor for their different opto-electronic properties.

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Regioselective animation of 3-Bromoindolylmaleimide with amines

3-Bromoindolylmaleimide and bisindolylmaleimide were synthesized from succinimide in three steps sequnence consisting of bromination, N-methylation and indole addition in the presence of magnesium and bromoethane. They were subjeced to the regioselective amination with substituted amines to provide 3-aminoindolylmaleimides, 3- amino-N-alkylated indolylmaleimides and N-alkylated bisindolylmaleimides in good yields. The resulting indolylmaleimides represent a new class of potentially bioactive compounds.

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Carbazole-based diphenyl maleimides: Multi-functional smart fluorescent materials for data process and sensing for pressure, explosive and pH

A series of carbazole-based diphenyl maleimide dyes with different N-substituent were synthesized through an Ullmann reaction in high yields. The dyes exhibit an intense emission in the solid state for their twisted conformation fixed by weak intermolecular interactions, resulting in the hindrance of the internal rotations. Their solid-stated emission wavelength and intensity are sensitive to external stimuli (like heat, pressure and vapor), due to a crystal-to-crystal or crystal-to-amorphous phase transition. Based on the multi-stimuli-responsive fluorescence properties of the N-benzyl analogue, two kinds of applications were explored. One is rewritable data recording processes including solvent writing and vapor writing. The other is sensing for low hydrostatic pressure (0-25 MPa). Interestingly, nanoparticles of the dyes formed in aqueous solution could effectively detect explosive and pH changes. A 15 ppm concentration of picric acid quenched the fluorescence of the N-methyl analogue with the detectable limit calculated to be 0.13 ppm. The N-methyl analogue also showed a different emission color and intensity over the pH range 12-14, which originated from the hydrolysis of the dye molecules in the strongly basic solution.

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I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1122-10-7, help many people in the next few years.Computed Properties of C4HBr2NO2

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C4HBr2NO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1122-10-7, name is 3,4-Dibromo-1H-pyrrole-2,5-dione. In an article£¬Which mentioned a new discovery about 1122-10-7

Synthesis of substituted bis(heteroaryl)maleimides

Substituted bis(fur-2-yl), bis(fur-3-yl) and bis(thien-2-yl) maleimides with potential antidiabetic properties are described. Their synthesis involves, as a key step, a Suzuki cross-coupling between various boron derivatives and the diiodomaleimides. Therefore, a wide range of substituted symmetric and non-symmetric maleimide derivatives can be prepared.

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Macrolactones built from the bis-3,4(indol-1-yl)maleimide scaffold

15, 16, and 17-Membered lactones based on the bis-3,4(indol-1-yl)maleimide framework were obtained using intramolecular esterification reaction starting from 3-(1-omega-carboxyalkyl-2,3-dihydroindol-1-yl)-4-(1-omega-hydroxyalkyl- 2,3-dihydroindol-1-yl)-maleimides. 3,4-Dibromo-maleimide, omega-(2,3- dihydroindol-3-yl)alkanoic acids, and omega-(2,3-dihydroindol-3-yl)alkanoles were used as starting compounds. Substitution of Br for the substituted indolines followed by the intramolecular cyclization of O-silylated hydroxyl acids derivatives led to macrolactones that incorporated 4-(dihydroindol-1-yl)- 3-(indol-1-yl)maleimide moieties. Indoline nuclei in these compounds were dehydrogenated by DDQ in refluxing toluene to give 15, 16 or 17-membered lactones 3-[(omega-3-carboxyalkylindol-1-yl)-4-(omega-hydroxyalkylindol-1- yl)maleimides. Quantum chemical calculations showed that the formation of macrolactones of smaller size (13-membered) corresponds to the higher Gibbs energy DeltaG# and correlates with the absence of the target reaction product.

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CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS

The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

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