114676-93-6, (2R,4R)-tert-Butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of Compound 10 (0.70 g, 3.48 mmol) and PPh3 (1.37 g, 5.22 mmol) in CH2Cl2 (7 mL) was added DEAD (0.91 mL, 5.22 mmol) at 4 C. [Zhao et al., Eur. J. Med. Chem. 2005, 40, 231]. The resulting mixture was stirred for 10 min and then 4-nitrobenzoic acid (1.62 g, 5.22 mmol) was added. This mixture was allowed to warm up to room temperature and stirred for 16 hours. The reaction mixture was quenched with 2 N NaOH solution and extracted with AcOEt. The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated. The residue was purified by flash column chromatography to give Compound 15 (0.885 g, 73%) as a pale yellow solid. Compound 15: 1H NMR (400 MHz, CDCl3): delta 1.38 (d, J=0.4 Hz, 3H), 1.48 (s, 9H), 1.96 (d, J=14.4 Hz, 1H), 2.47 (m, 1H), 3.64-3.83 (m, 2H), 4.11 (m, 1H), 5.55 (m, 1H), 8.21 (d, J=8.0 Hz, 2H), 8.31 (d, J=8.0 Hz, 2H).
114676-93-6, The synthetic route of 114676-93-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Tanaka, Fujie; Barbas, Carlos F.; Zhang, Haile; US2007/117986; (2007); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem