151038-94-7| - Heterocyclic Building Blocks-Pyrrolines

Derivation of elementary reaction about 151038-94-7

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate, you can also browse my other articles.

151038-94-7, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.151038-94-7, name is 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate. A new synthetic method of this compound is introduced below.

8 mg (7.5 mumol) of N-(3-carboxypropyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(2S,3E)-1-phenyl-4-(4-sulphophenyl)but-3-en-2-yl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 2.8 mg (8.2 mumol) of 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide trifluoroacetate, 3.4 mg (9 mumol) of HATU and 3.9 mul of Huenig’s base were stirred in 0.77 ml of DMF at RT for 20 h. Subsequently, the reaction mixture was purified by prep. HPLC. [2213] 3 mg (31% of theory) of the title compound were obtained. [2214] LC-MS (Method 1): Rt=0.90 min; MS (ESIpos): m/z=1164 (M+H)+, 151038-94-7

Reference£º
Patent; Lerchen, Hans-Georg; Hammer, Stefanie; Harrenga, Axel; Kopitz, Charlotte Christine; Nising, Carl Friedrich; Sommer, Anette; Stelte-Luowig, Beatrix; Mahlert, Christoph; Schuhmacher, Joachim; Golfier, Sven; Greven, Simone; Bruder, Sandra; US2015/23989; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Fun Route: New Discovery of H-Ala-OH

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 151038-94-7. We look forward to the emergence of more reaction modes in the future.

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 151038-94-7, name is 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate, introduce a new downstream synthesis route., 151038-94-7

[00246] Acetate 4-(1 -(2-(6-(2,5-dioxo-2H-pyrrol-1 (5H)- yl)hexanoyl)hydrazono)ethyl)benzoate oxaliplatin was synthesized using acetoxyoxalplatin(4-acetylphenyl)carboxylate (328 mg, 0.529 mmol, 1 .00 equiv) that was dissolved in DMF (0.05 M, 10 mL) and treated with 6-(2,5-dioxo-2,5- dihydro-1 H-pyrrol-1 -yl)hexanehydrazide TFA salt (359 mg, 1 .05 mmol, 2.00 equiv). The reaction mixture was stirred at room temperature for 16 hours. MTBE was added to the reaction mixture until a gum was formed and the solvent was decanted. To the gummy residue was added more MTBE and the mixture was incubated in an ultrasonic bath until the gum turned into a yellow solid. The solid was filtered and rinsed with MTBE to afford compound 15(126 mg, 29%, 93.2% pure); 1 H NMR (500 MHz, DMF-d7) delta 10.50 (s, 0.4H), 10.42 (s, 0.6H), 8.95-8.44 (m, 4H), 7.92-7.88 (m, 4H), 7.03 (s, 0.8H), 7.02 (s, 1 .2H), 3.62-3.35 (m, 6H), 2.46-2.33 (m, 5H), 1 .98 (s, 3H), 1 .78-1 .50 (m, 8H), 1 .43-1 .22 (m, 4H); HPLC-MS 93.2%, m/z for C29H37N501 1 Pt [(M+H)+] = 828.3, 151038-94-7

Reference£º
Patent; BLEND THERAPEUTICS, INC.; MOREAU, Benoit; BILODEAU, Mark T.; WHALEN, Kerry; MEETZE, Kristan; SINGH, Sukhjeet; WOOSTER, Richard; LEMELIN, Charles-Andre; (139 pag.)WO2015/200250; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

The effect of 151038-94-7 reaction temperature change on equilibrium

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 151038-94-7

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.151038-94-7, name is 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate. Here is a downstream synthesis route of the compound 151038-94-7. 151038-94-7

[00250] Acetoxycisplatin(4-acetylphenyl)carboxylate (178 mg, 0.341 mmol, 1 equiv) was dissolved in DMF (0.05 M, 6.8 mL) and treated with 6-(2,5-dioxo-2,5- dihydro-1 H-pyrrol-1 -yl)hexanehydrazide TFA salt (139 mg, 0.409 mmol, 1 .2 equiv). The reaction mixture was stirred at room temperature for 5 hours. MTBE was added to the reaction mixture until a suspension was obtained and a yellow solid was filtered to afford compound 17 (159 mg, 64%, 97% pure). 1H NMR (500 MHz, DMF-d7) delta 10.48 (s, 0.3H), 10.40 (s, 0.6H), 7.97-7.92 (m, 2H), 7.91 -7.86 (m, 2H), 7.24-6.77 (m, 6H), 7.02 (s, 2H), 3.50-3.44 (m, 2H), 2.77-2.72 (m, 1 .4H), 2.44-2.38 (m, 0.6H), 2.40 (s, 2H), 2.37 (s, 1 H), 1 .94 (s, 3H), 1 .73-1 .64 (m,2H), 1 .63-1 .54 (m, 2H), 1 .42-1 .29 (m, 2H); HPLC-MS 98%, m/z for CziHzgC NsOyPt [(M+H)+] = 730.2.

Little discovery in the laboratory: a new route for 151038-94-7

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.151038-94-7, name is 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate, below Introduce a new synthetic route., 151038-94-7

151038-94-7, [4593] 8 mg (7.5 f.tmol) ofN-(3-carboxypropyl)-N-methylL-valyl-N -[ (3R,4S,5S)-3-methoxy-1-{ (2S)-2-[ (1 R,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2S,3E)-1-phenyl-4-( 4-sulphophenyl)but-3-en-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 2.8 mg(8.2 f.tmol) of 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazidetrifluoroacetate, 3.4 mg (9 f.tmol) ofHATU and3.9 fll ofHunig’s base were stirred in 0.77 ml ofDMF at RTfor 20 h. Subsequently, the reaction mixture was purified bymeans of preparative HPLC.[4594] 3 mg (31% of theory) of the title compound wereobtained.[4595] LC-MS (Method 1): R,=0.90 min; MS (ESipos):m/z=1164 (M+Ht

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Little discovery in the laboratory: a new route for 151038-94-7

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 151038-94-7, you can also browse my other articles.

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.151038-94-7, name is 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate. A new synthetic method of this compound is introduced below., 151038-94-7

[00247] Acetoxyoxaliplatin(4-acetylphenyl)carbamate was first synthesized using acetoxy(hydroxyl)oxaliplatin (243 mg, 0.51 mmol, 1 .00 equiv) and 4- acetylphenylisocyanate (124 mg, 0.77 mmol, 1 .50 equiv) dissolved in DMF (0.1 M, 5 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated and impregnated on silica gel. The crude product was purified by normal phase chromatography using silica gel column (40 g) eluted with 5-20% MeOH / CH2CI2 gradient over 15 minutes. Pure fractions were combined and concentrated under vacuum to provide the product as a yellow solid (241 mg, 74%, 83% pure). HPLC-MS 83.1 %, m/z for CigHzsNsOgPt +H)+] = 635.2. 16 [00248] Synthesis of acetate 4-(1-(2-(6-(2,5-dioxo-2H-pyrrol-1(5H)- l)hexanoyl)hydrazono)ethyl) phenyl carbamate oxaliplatin: Acetoxyoxalplatin(4- acetylphenyl)carbamate (228 mg, 0.36 mmol, 1 .00 equiv) was dissolved in DMF (0.05 M, 7 mL) and treated with 6-(2,5-dioxo-2,5-dihydro-1 H-pyrrol-1 – yl)hexanehydrazide TFA salt (158 mg, 0.47 mmol, 1 .30 equiv). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated and the residue was triturated with acetonitrile to precipitate the product as a yellow powder. This powder was triturated first with isopropyl alcohol (iPrOH) and then with DCM to afford the desired product (70 mg, 23%, 93.5% pure). HPLC-MS 93.5%, m/z for CzgHssNeOu Pt [(M+H)+] = 842.3. 1 H NMR (500 MHz, DMF-d7) 5 10.34-10.15 (m, 1 H), 9.91 -9.66 (m, 1 H), 9.37-9.24 (m, 1 H), 8.88-8.66 (m, 2H), 8.59-8.48 (m, 1 H), 7.80-7.73 (m, 2H), 7.61 -7.53 (m, 2H), 7.04-6.98 (m, 2H), 3.50-3.43 (m, 2H), 3.14-3.02 (m, 1 H), 2.75-2.70 (m, 1 H), 2.43-2.25 (m, 6H), 2.01 -1 .92 (m, 3H), 1 .74-1 .53 (m, 9H), 1 .42-1 .24 (m, 4H)., 151038-94-7

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 151038-94-7, you can also browse my other articles.

Simple exploration of 151038-94-7

151038-94-7, 151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.

151038-94-7, 151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Simple exploration of 151038-94-7

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Brief introduction of 151038-94-7

151038-94-7, The synthetic route of 151038-94-7 has been constantly updated, and we look forward to future research findings.

[4611] 10 mg (9.3 f.tmol) of N-(3-carboxypropyl)-N-methyl-L-valyl-N -[ (3R,4S,5S)-3-methoxy-l-{ (2S)-2-[ (lR,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2R)-1-phenyl-4-( 4-sulphophenyl)butan-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 3.5 mg(10.3 flillOI) of 6-(2,5-dioxo-2,5-dihydro-lH-pyrrol-1-yl)hexanehydrazide trifluoroacetate, 4.3 mg (11.2 f.tmol) ofHATU and 4.9 fll (28 f.tmol) ofHlinig’s base were stirred in 1ml ofDMF at RT for 20 h. Subsequently, the reaction mixturewas purified by means of preparative HPLC. 4.2 mg (92%purity, 33% of theory) of the title compound were obtained.[4612] LC-MS (Method 1): R,=0.91 min; MS (ESipos):m/z=1166 (M+Ht

151038-94-7, The synthetic route of 151038-94-7 has been constantly updated, and we look forward to future research findings.

New learning discoveries about 151038-94-7

As the paragraph descriping shows that 151038-94-7 is playing an increasingly important role.

151038-94-7, 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetoxycisplatin(4-acetylphenyl)carbamate (215 mg, 0.400 mmol, 1 .0 equiv) was dissolved in DMF (0.05M, 8 mL) and treated with 6-(2,5-dioxo-2,5-dihydro-1 H- pyrrol-1 -yl)hexanehydrazide TFA salt (163 mg, 0.480 mmol, 1 .2 equiv) at room temprature. The reaction mixture was stirred at room temperature overnight. Dichloromethane was added to the reaction mixture and the suspension was filtered to provide a yellow solid (230mg, 77% yield, 90.9% pure). The residue obtained was triturated with MeCN to provide compound 18 as a yellow solid (144 mg, 48% yield, 97.3% pure). 1H NMR (500 MHz, DMF-d7) delta 10.28 (s, 0.4H), 10.15 (s, 0.6H), 9.74 (brs, 1 H), 7.79-7.72 (m, 2H), 7.61 -7.54 (m, 2H), 7.22-6.81 (m, 6H), 7.02 (s, 2H), 3.50-3.44 (m, 2H), 2.74-2.70 (m, 1 .2H), 2.40-2.35 ( m, 0.8H), 2.33 (s, 2H), 2.29 (s, 1 H), 1 .93 (s, 3H), 1 .72-1 .63 (m, 2H), 1 .62-1 .53 (m, 2H), 1 .42-1 .29 (m, 2H); HPLC-MS 97%, m/z for CziHsoC NeOyPt [(M+H)+] = 745.2., 151038-94-7

As the paragraph descriping shows that 151038-94-7 is playing an increasingly important role.

Some tips on 151038-94-7

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

1 mmol of doxorubicin, 3 mmol of 6-maleimidocaproyl hydrazide trifluoroacetate, mix 20mL of methanol and 0.01mL of trifluoroacetic acid, in the dark,The nucleophilic addition reaction was carried out at 20 C for 24 h; the obtained system was mixed with ethanol, and then subjected to precipitation and ultrafiltration centrifugation, and the obtained concentrated material was lyophilized. Obtaining maleimide functionalized doxorubicin; 1 mmol of KLAK peptide with a cysteine at the N-terminus, 15 mmol of tris(2-carbonylethyl)phosphoric acid hydrochloride and 10 mL of phosphate buffer solution (concentration: 20 mmol/L, pH 7.4) were mixed, and stirred at 25 C for 1 h; Then add 3 mmol of maleimide functionalized doxorubicin, adding reaction under stirring at 25 C for 2 h; the obtained system was allowed to stand at 4 C for 22 h, and then subjected to ultrafiltration centrifugation. The resulting concentrated material is lyophilized, an anti-tumor peptide-doxorubicin derivative is obtained., 151038-94-7

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Beihua University; Guan Xingang; Xia Wei; Chen Li; (11 pag.)CN109675051; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem