With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.186550-13-0,1-Boc-3-Aminopyrrolidine,as a common compound, the synthetic route is as follows.
2-Chloro-5-((6-fluoro-2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)benzoic acid (700 mg,2.00mmol),EDC (770 mg, 4.00 mmol),HOBt (540 mg, 4.00 mmol), DIEA (0.9 mL, 5.00 mmol) and compound 1-Boc-3-aminopyrrolidine (400 mg, 2.08 mmol) were dissolved in anhydrous DMF (20 mL).The reaction was carried out overnight at room temperature under argon gas protection. Stop the reaction,The reaction was diluted with DCM / MeOH (10:1, 60 mL).The organic phase was saturated with sodium bicarbonate (30 mL).Wash with saturated ammonium chloride (30 mL) and saturated brine (30 mL¡Á3).Drying over MgSO 4, EtOAc (EtOAc)Recrystallization from DCM/PE gave a pale yellow solid 890mg.The yield is 85.6%.
186550-13-0, As the paragraph descriping shows that 186550-13-0 is playing an increasingly important role.
Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Zhao Hailong; Ji Ming; Zhou Jie; Wang Liyuan; Yao Haiping; Jin Jing; (107 pag.)CN108727343; (2018); A;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem