Final Thoughts on Chemistry for 1,1′-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)

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MONODISPERSE MICROSPHERES AND METHOD OF PREPARING SAME

The present invention includes microspheres prepared using step-growth dispersion click chemistry polymerization. In certain embodiments, the click chemistry polymerization comprises thiol-ene polymerization and/or thiol-Michael polymerization. In other embodiments, the microspheres are near-monodisperse and/or monodisperse. In yet other embodiments, the microspheres have a glass transition temperature (Tg) in the range of ?50 C. to 100 C. The present invention further includes a method of making the same.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Archives for Chemistry Experiments of 28537-70-4

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Formation of a beta-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

The beta-barrel assembly machine (Bam) complex in Gram-negative bacteria and its counterparts in mitochondria and chloroplasts fold and insert outer membrane beta-barrel proteins. BamA, an essential component of the complex, is itself a beta-barrel and is proposed to play a central role in assembling other barrel substrates. Here, we map the path of substrate insertion by the Bam complex using site-specific crosslinking to understand the molecular mechanisms that control beta-barrel folding and release. We find that the C-terminal strand of the substrate is stably held by BamA and that the N-terminal strands of the substrate are assembled inside the BamA beta-barrel. Importantly, we identify contacts between the assembling beta-sheet and the BamA interior surface that determine the rate of substrate folding. Our results support a model in which the interior wall of BamA acts as a chaperone to catalyze beta-barrel assembly.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem