You could be based in a university, combining chemical research with teaching; working on developing and trialing new drugs; or helping to ensure national healthcare provision keeps pace with new discoveries. 3446-89-7, Name is 4-(Methylthio)benzaldehyde, molecular formula is C8H8OS, belongs to pyrrolines compound, is a common compound. In a patnet, author is JIE, MSFLK, once mentioned the new application about 3446-89-7, Safety of 4-(Methylthio)benzaldehyde.
ULTRASOUND IN FATTY-ACID CHEMISTRY – SYNTHESIS OF A 1-PYRROLINE FATTY-ACID ESTER ISOMER FROM METHYL RICINOLEATE
A novel 1-pyrroline fatty acid ester isomer [viz. 8-(5-hexyl-1-pyrrolin-2-yl)octanoate] has been synthesized from methyl ricinoleate by two routes with an overall yield of 42 and 30%, respectively. Most of the reactions are carried out under concomitant ultrasonic irradiation (20 KHz, ca. 53 watts/cm(2)). Under such a reaction condition, the reaction time is considerably shortened, and product yields are high. Dehydrobromination under concomitant ultrasonic irradiation of methyl 9,10-dibromo-12-hydroxyoctadecanoate with KOH in EtOH furnishes methyl 12-hydroxy-9-octadecynoate (66%) within 15 min. Hydration of the latter under ultrasound with mercury(II)acetate in aqueous tetrahydrofuran yields exclusively methyl 12-hydroxy-9-oxo-octadecanoate (95%) in 30 min. The hydroxy group in the latter compound is transformed to the azido function via the mesylate, and treatment of the azido-oxo intermediate (methyl 12-azido-9-oxooctadecanoate) with Ph(3)P under ultrasonic irradiation furnishes the requisite 1-pyrroline fatty acid ester (77%). The same azido-oxo intermediate has also been obtained by the oxidation of methyl 12-azido-9-cis-octadecenoate using benzoquinone and a catalytic amount of Pd(II)chloride in aqueous tetrahydrofuran under concomitant ultrasonic irradiation (90 min) to give the product in 45% yield. The latter reaction does not take place even the reaction mixture.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3446-89-7. Safety of 4-(Methylthio)benzaldehyde.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem