392338-15-7, (R)-tert-Butyl methyl(pyrrolidin-3-yl)carbamate is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
UILK-I-17 (26) (50 mg, 0.13 mmol) was dissolve in DMSO (1 mL)and (R)-tert-Butyl [[pyrrolidin-3-yl]methyl]carbamate (53 mg,0.26 mmol) and DIPEA (100 mL) were added. The reaction washeated to 30 C and stirred for 21 h. To the crude reaction product1mL of 4 N aqueous hydrochloric acid and 5mL of ACN were addedand stirred for 24 h. The ACN was removed by rotatory evaporationand the remaining aqueous layer was frozen and lyophilized. PureUIJD-III-118 (5h) was isolated, 60 mg, 75%. 1H NMR (300 MHz, MeOD) d 9.45 (exchangeable) (bs, 2H), 9.22 (s, 1H), 7.86 (d,J 14.2 Hz, 1H), 7.67 (dd, J 15.0, 7.8 Hz, 3H), 7.49e7.41 (m, 3H),7.37 (d, J 7.2 Hz, 1H), 6.75 (d, J 7.4 Hz, 1H), 5.86 (s, 2H),3.85e3.66 (m, 4H), 3.58e3.46 (m, 1H), 2.59 (m, 3H), 2.31 (m, 2H).19F NMR (282 MHz, MeOD) d 126.52 to 126.83 (m). MS ESIcalculated for (M H) 472.2, found 472.2. Retention time(analytical HPLC) 19.5 min., 392338-15-7
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Reference£º
Article; Delgado, Justine L.; Lentz, Sarah R.C.; Kulkarni, Chaitanya A.; Chheda, Pratik R.; Held, Hailey A.; Hiasa, Hiroshi; Kerns, Robert J.; European Journal of Medicinal Chemistry; vol. 172; (2019); p. 109 – 130;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem