Category: 4045-24-3

Name: 4-Methoxypiperidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive. Author is Han, Dongyang; Li, Sasa; Xia, Siqi; Su, Mincong; Jin, Jian.

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

Different reactions of this compound(4-Methoxypiperidine)Name: 4-Methoxypiperidine require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities, published in 2021-05-13, which mentions a compound: 4045-24-3, mainly applied to thiophene arylamide derivative design synthesis DprE1 inhibitor; antimycobacterial activity DprE1 inhibitor thiophene arylamide derivative SAR; mol docking pharmacokinetic property selected thiophene arylamide, Synthetic Route of C6H13NO.

In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy. Systematic optimization of the two side chains flanking the thiophene core led to new lead compounds bearing a thiophene-arylamide scaffold with potent antimycobacterial activity and low cytotoxicity. Compounds I, II, III [X = H,F] exhibited potent in vitro activity against both drug-susceptible (min. inhibitory concentration (MIC) = 0.02-0.12μg/mL) and drug-resistant (MIC = 0.031-0.24μg/mL) tuberculosis strains while retaining potent DprE1 inhibition (half maximal inhibitory concentration (IC50) = 0.2-0.9μg/mL) and good intracellular antimycobacterial activity. In addition, these compounds showed good hepatocyte stability and low inhibition of the human ether-á-go-go related gene (hERG) channel. The representative compound III [X = H] with acceptable pharmacokinetic property demonstrated significant bactericidal activity in an acute mouse model of tuberculosis. Moreover, the mol. docking study of template compound I provides new insight into the discovery of novel antitubercular agents targeting DprE1.

Different reactions of this compound(4-Methoxypiperidine)Synthetic Route of C6H13NO require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Copper-Catalyzed 3-Positional Amination of 2-Azulenols with O-Benzoylhydroxylamines, published in 2021-09-03, which mentions a compound: 4045-24-3, mainly applied to azulenol benzoylhydroxylamine copper catalyst regioselective amination; aminoazulenol preparation, Related Products of 4045-24-3.

A copper-catalyzed ortho-selective amination of 2-azulenols with O-benzoylhydroxylamines (RR’N-OBz) to synthesize ortho-aminoazulenols was reported. A wide range of functional groups on amines were compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields. The further synthetic elaboration using 3-amino-2-azulenols as starting materials was demonstrated.

Different reactions of this compound(4-Methoxypiperidine)Related Products of 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Lei, Jie; Li, Yong; Xu, Jia; Tang, Dian-Yong; Shao, Jing-Wei; Li, Hong-yu; Chen, Zhong-Zhu; Xu, Zhi-Gang published the article 《An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water》. Keywords: amine isocyanide chromone carboxaldehyde formic acid Ugi type addition; alkylaminomethylene oxochromane carboxamide preparation diastereoselective chemoselective green chem.They researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Name: 4-Methoxypiperidine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4045-24-3) here.

A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. The hydrogen bond can dictate the stereo-outcome of olefins and provided an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.

Different reactions of this compound(4-Methoxypiperidine)Name: 4-Methoxypiperidine require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kabeche, Stephanie; Aida, Jumpei; Akther, Thamina; Ichikawa, Takashi; Ochida, Atsuko; Pulkoski-Gross, Michael J.; Smith, Mark; Humphries, Paul S.; Yeh, Ellen researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Product Details of 4045-24-3.They published the article 《Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS》 about this compound( cas:4045-24-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: azepanylpropyl azaheterocyclylalkyl arylthiazolecarboxamide heteroarylcarboxamide preparation antimalarial agent; structure azaheterocyclylalkyl arylthiazolecarboxamide inhibition malarial farnesyldiphosphate geranylgeranyldiphosphate synthase; lipophilicity solubility biol permeation metabolism antimalarial activity azepanylpropyl arylthiazolecarboxamide; Farnesyl/Geranylgeranyl diphosphate synthase; Malaria; Plasmodium falciparum; SAR; Thiazole. We’ll tell you more about this compound (cas:4045-24-3).

A series of novel thiazole-containing amides such as I.TFA were synthesized as inhibitors of Plasmodium falciparum farnesyldiphosphate synthase (PfFPPS) and geranylgeranyldiphosphate synthase (PfGGPPS). A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising candidate mols. were progressed to mouse in vivo PK studies and demonstrated adequate free drug exposure to warrant further investigation.

Different reactions of this compound(4-Methoxypiperidine)Product Details of 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

HPLC of Formula: 4045-24-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Electrochemical Nonacidic N-Nitrosation/N-Nitration of Secondary Amines through a Biradical Coupling Reaction.

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines/azoles with Fe(NO3)3 · 9H2O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed to give nitroso-amines I [R = piperidin-1-yl, pyrrolidin-1-yl, morpholin-4-yl, etc.] and nitro-azoles II [R1 = 3-Me-pyrazol-1-yl, imidazol-1-yl, benzotriazol-1-yl, etc.] under mild conditions. Control and competition experiments, as well as kinetic studies demonstrated that N-nitrosation and N-nitration involved two different radical reaction pathways involving N+ and N. radicals. Moreover, the electrocatalysis method enabled the preferential activation of the N-H bond over the electrode and thus provided high selectivity for specific N atoms. This strategy exhibited a broad scope and provided a green and straightforward approach to generate useful compounds I and II in good yields.

Different reactions of this compound(4-Methoxypiperidine)HPLC of Formula: 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electrochemical Iodoamination of Indoles Using Unactivated Amines, published in 2020-12-04, which mentions a compound: 4045-24-3, Name is 4-Methoxypiperidine, Molecular C6H13NO, Related Products of 4045-24-3.

An environmentally friendly electrochem. approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of 131I-labeled compounds Fundamental insights into the mechanism of the reaction based on control experiments, d. functional theory calculation, and cyclic voltammetry are provided.

Different reactions of this compound(4-Methoxypiperidine)Related Products of 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: 4045-24-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities.

In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy. Systematic optimization of the two side chains flanking the thiophene core led to new lead compounds bearing a thiophene-arylamide scaffold with potent antimycobacterial activity and low cytotoxicity. Compounds I, II, III [X = H,F] exhibited potent in vitro activity against both drug-susceptible (min. inhibitory concentration (MIC) = 0.02-0.12μg/mL) and drug-resistant (MIC = 0.031-0.24μg/mL) tuberculosis strains while retaining potent DprE1 inhibition (half maximal inhibitory concentration (IC50) = 0.2-0.9μg/mL) and good intracellular antimycobacterial activity. In addition, these compounds showed good hepatocyte stability and low inhibition of the human ether-á-go-go related gene (hERG) channel. The representative compound III [X = H] with acceptable pharmacokinetic property demonstrated significant bactericidal activity in an acute mouse model of tuberculosis. Moreover, the mol. docking study of template compound I provides new insight into the discovery of novel antitubercular agents targeting DprE1.

Different reactions of this compound(4-Methoxypiperidine)Recommanded Product: 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive, published in 2020-09-28, which mentions a compound: 4045-24-3, mainly applied to aryl halide amine amination coupling nickel catalyst regioselective chemoselective; C−N coupling; amination; anilines; aryl halides; nickel catalysis, HPLC of Formula: 4045-24-3.

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

Different reactions of this compound(4-Methoxypiperidine)HPLC of Formula: 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Photoredox B-H functionalization to selective B-N(sp3) coupling of nido-carborane with primary and secondary amines, the main research direction is crystal structure mol carborane amino nitrogen containing preparation heterocyclic; photoredox catalyst selective coupling nido carborane primary secondary amine.Reference of 4-Methoxypiperidine.

Access to nido-carborane site-selective B-N(sp3) coupling by photoredox catalyzed B-H activation has been achieved for the first time, which leads to the synthesis of a series of nitrogen-containing nido-carboranes with moderate to good yields. This protocol is applicable to primary and secondary amines containing alkyl, or heteroaryl groups as well as sulfonamides. Furthermore, the open to air and metal-free conditions with excellent site-selectivity represent a significant improvement for B-H functionalization of nido-carboranes with organic functionalities.

Different reactions of this compound(4-Methoxypiperidine)Reference of 4-Methoxypiperidine require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem