Category: 4045-24-3

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water, published in 2020, which mentions a compound: 4045-24-3, mainly applied to amine isocyanide chromone carboxaldehyde formic acid Ugi type addition; alkylaminomethylene oxochromane carboxamide preparation diastereoselective chemoselective green chem, Category: pyrrolines.

A green 1,4-addition isocyanide-based three-component reaction was developed to synthesize chromanones via a facile, mild, and efficient one-pot protocol without a metal catalyst. The 1,4-addition of isocyanides occurred at the C-2 position of chromones instead of the Schiff base in neat water. The hydrogen bond can dictate the stereo-outcome of olefins and provided an effective method for the diastereomer-selective synthesis of this type of chromanone. The novel green synthetic protocol allowed the quick synthesis of complex chromanones in an environmentally friendly manner.

Different reactions of this compound(4-Methoxypiperidine)Category: pyrrolines require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Application of 4045-24-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive. Author is Han, Dongyang; Li, Sasa; Xia, Siqi; Su, Mincong; Jin, Jian.

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

Different reactions of this compound(4-Methoxypiperidine)Application of 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Synthetic Route of C6H13NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Three-component radical homo Mannich reaction. Author is Shi, Shuai; Qiu, Wenting; Miao, Pannan; Li, Ruining; Lin, Xianfeng; Sun, Zhankui.

By employing a radical process, enolizable aldehydes were utilized as substrates in the three-component radical homo-Mannich reaction for the streamlined synthesis of γ-amino-carbonyl compounds. The electrophilic radicals were generated from thiols HSCHR1C(O)R2 (R1 = H, Me; R2 = Me, EtO, PhCH2O, 1-adamantyl, Et2N, etc.) via the desulfurization process facilitated by visible-light, and then added to the electron-rich double bonds of enamines, formed in-situ from aldehydes or ketones R3CH2C(O)R4 [R3 = H, Et, MeSCH2, Ph, PhCH2, etc., R4 = H; R3 = H, R4 = Ph, 3-FC6H4, etc.; R3R4 = (CH2)5, CH2CHPhCH2CH2, CH2N(CH2Ph)CH2CH2, etc.] and amines R5NHR6 [R5 = Me, R6 = H2C:CHCH2, PhCH2, cyclohexyl, etc.; R5 = PhCH2, R6 = PhCH2, EtO2CCH2, etc.; R5R6 = (CH2)4, CHPh(CH2)3, etc.] to provide the products I in a single step. The broad scope, mild conditions, high functional group tolerance, and modularity of this metal-free approach for the synthesis of complex tertiary amine scaffolds will likely be of great utility to chemists in both academia and industry.

Different reactions of this compound(4-Methoxypiperidine)Synthetic Route of C6H13NO require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4045-24-3, is researched, SMILESS is COC1CCNCC1, Molecular C6H13NOJournal, Article, Organic Letters called Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation, Author is An, Yang; Li, Yuke; Zhang, Xiao-Yan; Zhang, Zhe; Gou, Xue-Ya; Ding, Ya-Nan; Li, Qiao; Liang, Yong-Min, the main research direction is amino fused bicyclic compound preparation regioselective; iodoarene benzoyloxyamine norbornadiene Catellani reaction amination cyclization palladium catalyst.Related Products of 4045-24-3.

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2+3] or [2+4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates ortho-substituents that avoid a second C-H palladation. The scope of substrates was broad, o-methyl-substituted iodoarenes R-2-CH3-C6H3I (R = H, 4-F, 3-Me, 4-Cl, etc.), 3-iodo-4-methyl-pyridine were applied to the reaction smoothly, and o-phenyl-substituted iodoarenes 2-I-C6H4-(4-R1C6H4-) (R1 = H, Me, Ph, F, etc.), 1-(2-iodo-phenyl)-naphthalene can also be obtained by this method. In terms of mechanism, d. functional theory calculations proved the sequence of the key five-membered aryl-norbornene-palladacycle intermediate formation and C(sp3 or sp2)-H activation.

The article 《Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation》 also mentions many details about this compound(4045-24-3)Related Products of 4045-24-3, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Han, Dongyang; Li, Sasa; Xia, Siqi; Su, Mincong; Jin, Jian researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Recommanded Product: 4045-24-3.They published the article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 about this compound( cas:4045-24-3 ) in Chemistry – A European Journal. Keywords: aryl halide amine amination coupling nickel catalyst regioselective chemoselective; C−N coupling; amination; anilines; aryl halides; nickel catalysis. We’ll tell you more about this compound (cas:4045-24-3).

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

The article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 also mentions many details about this compound(4045-24-3)Recommanded Product: 4045-24-3, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer, published in 2021-01-15, which mentions a compound: 4045-24-3, mainly applied to pyrimidine human colorectal cancer anticancer apoptosis; AMP-Activated protein kinase (AMPK); Colorectal cancer; NUAK; WZ4003 derivatives, COA of Formula: C6H13NO.

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound I, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, I suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation.

The article 《Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer》 also mentions many details about this compound(4045-24-3)COA of Formula: C6H13NO, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

HPLC of Formula: 4045-24-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Three-component radical homo Mannich reaction. Author is Shi, Shuai; Qiu, Wenting; Miao, Pannan; Li, Ruining; Lin, Xianfeng; Sun, Zhankui.

By employing a radical process, enolizable aldehydes were utilized as substrates in the three-component radical homo-Mannich reaction for the streamlined synthesis of γ-amino-carbonyl compounds. The electrophilic radicals were generated from thiols HSCHR1C(O)R2 (R1 = H, Me; R2 = Me, EtO, PhCH2O, 1-adamantyl, Et2N, etc.) via the desulfurization process facilitated by visible-light, and then added to the electron-rich double bonds of enamines, formed in-situ from aldehydes or ketones R3CH2C(O)R4 [R3 = H, Et, MeSCH2, Ph, PhCH2, etc., R4 = H; R3 = H, R4 = Ph, 3-FC6H4, etc.; R3R4 = (CH2)5, CH2CHPhCH2CH2, CH2N(CH2Ph)CH2CH2, etc.] and amines R5NHR6 [R5 = Me, R6 = H2C:CHCH2, PhCH2, cyclohexyl, etc.; R5 = PhCH2, R6 = PhCH2, EtO2CCH2, etc.; R5R6 = (CH2)4, CHPh(CH2)3, etc.] to provide the products I in a single step. The broad scope, mild conditions, high functional group tolerance, and modularity of this metal-free approach for the synthesis of complex tertiary amine scaffolds will likely be of great utility to chemists in both academia and industry.

The article 《Three-component radical homo Mannich reaction》 also mentions many details about this compound(4045-24-3)HPLC of Formula: 4045-24-3, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Reference of 4-Methoxypiperidine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. Author is Tawada, Michiko; Fushimi, Makoto; Masuda, Kei; Sun, Huikai; Uchiyama, Noriko; Kosugi, Yohei; Lane, Weston; Tjhen, Richard; Endo, Satoshi; Koike, Tatsuki.

O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chem. tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report the discovery of a potent and novel OGA inhibitor, compound 5i, comprising an aminopyrimidine scaffold, identified by virtual screening based on multiple methodologies combining structure-based and ligand-based approaches, followed by sequential optimization with a focus on ligand lipophilicity efficiency. This compound was observed to increase the level of O-GlcNAcylated protein in cells and display suitable pharmacokinetic properties and brain permeability. Crystallog. anal. revealed that the chem. series bind to OGA via characteristic hydrophobic interactions, which resulted in a high affinity for OGA with moderate lipophilicity. Compound 5i could serve as a useful chem. probe to help establish a proof-of-concept of OGA inhibition as a therapeutic target for the treatment of tauopathies.

The article 《Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization》 also mentions many details about this compound(4045-24-3)Reference of 4-Methoxypiperidine, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Han, Dongyang; Li, Sasa; Xia, Siqi; Su, Mincong; Jin, Jian researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).SDS of cas: 4045-24-3.They published the article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 about this compound( cas:4045-24-3 ) in Chemistry – A European Journal. Keywords: aryl halide amine amination coupling nickel catalyst regioselective chemoselective; C−N coupling; amination; anilines; aryl halides; nickel catalysis. We’ll tell you more about this compound (cas:4045-24-3).

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

The article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 also mentions many details about this compound(4045-24-3)SDS of cas: 4045-24-3, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cao, Yanwei; Yang, Jian-Gong; Deng, Yi; Wang, Shengchun; Liu, Qi; Shen, Chaoren; Lu, Wei; Che, Chi-Ming; Chen, Yong; He, Lin researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Computed Properties of C6H13NO.They published the article 《Amine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation》 about this compound( cas:4045-24-3 ) in Angewandte Chemie, International Edition. Keywords: amine gold copper salt oxidative carbonylation synergistic catalyst; carbamates; double salts; oxidative carbonylation; synergistic catalysis; urea. We’ll tell you more about this compound (cas:4045-24-3).

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its use for the synergistic catalysis was enlightened. Study of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]- on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)sym. ureas and carbamates.

Different reactions of this compound(4-Methoxypiperidine)Computed Properties of C6H13NO require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem