Category: 4045-24-3

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4045-24-3, is researched, Molecular C6H13NO, about Sustainable Route Toward N-Boc Amines: AuCl3/CuI-Catalyzed N-tert-butyloxycarbonylation of Amines at Room Temperature, the main research direction is tertiary butoxycarbonyl amine preparation green chem; amine alc carbon monoxide tertiary butyloxycarbonylation gold copper catalyst; N-tert-butyloxycarbonylation; amines; gold catalysis; homogeneous catalysis; synergistic effect.Synthetic Route of C6H13NO.

Herein, a step- and atom-economic synthesis of N-Boc amines RC(O)OC(CH3)3 (R = diethylaminyl, piperidin-1-yl, 4-methylpiperazin-1-yl, 1,4-dioxa-8-azaspiro[4.5]decan-8-yl, etc.) from amines RH, t-butanol, and CO was reported at room temperature Notably, this N-tert-butyloxycarbonylation procedure utilized ready-made substrates, com. available AuCl3/CuI as catalysts, and O2 from air as the sole oxidant. This catalytic system provided unique selectivity for N-Boc amines in good yields. More significantly, gram-scale preparation of medicinally important N-Boc amine intermediates was successfully implemented and, which demonstrated a potential application prospect in industrial syntheses. Furthermore, this approach also showed good compatibility with tertiary and other useful alcs. R1OH (R1 = t-Bu, 2-methylbutan-2-yl, Bn, etc.). Investigations of the mechanisms revealed that gold catalyzed the reaction and copper acted as electron transfer mediator in the catalytic cycle.

Compounds in my other articles are similar to this one(4-Methoxypiperidine)Synthetic Route of C6H13NO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration, Author is Wang, Jin-Lin; Liu, Mei-Ling; Zou, Jian-Yu; Sun, Wen-Hui; Liu, Xue-Yuan, which mentions a compound: 4045-24-3, SMILESS is COC1CCNCC1, Molecular C6H13NO, HPLC of Formula: 4045-24-3.

A new strategy for aminoarylation of alkenes by copper-catalyzed SMILESs rearrangement using O-benzoylhydroxylamines as the amine reagent was described.. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

Compounds in my other articles are similar to this one(4-Methoxypiperidine)HPLC of Formula: 4045-24-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.Synthetic Route of C6H13NO.

A series of novel thiazole-containing amides such as I.TFA were synthesized as inhibitors of Plasmodium falciparum farnesyldiphosphate synthase (PfFPPS) and geranylgeranyldiphosphate synthase (PfGGPPS). A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising candidate mols. were progressed to mouse in vivo PK studies and demonstrated adequate free drug exposure to warrant further investigation.

Compounds in my other articles are similar to this one(4-Methoxypiperidine)Synthetic Route of C6H13NO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Quality Control of 4-Methoxypiperidine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Amine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation. Author is Cao, Yanwei; Yang, Jian-Gong; Deng, Yi; Wang, Shengchun; Liu, Qi; Shen, Chaoren; Lu, Wei; Che, Chi-Ming; Chen, Yong; He, Lin.

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its use for the synergistic catalysis was enlightened. Study of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]- on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)sym. ureas and carbamates.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Quality Control of 4-Methoxypiperidine and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Sun, Yan; Fu, Rong; Lin, Songwen; Zhang, Jingbo; Ji, Ming; Zhang, Yan; Wu, Deyu; Zhang, Kehui; Tian, Hua; Zhang, Mingyi; Sheng, Li; Li, Yan; Jin, Jing; Chen, Xiaoguang; Xu, Heng published the article 《Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors》. Keywords: PI3K inhibitor thienopyrimidine thiazolopyrimidine synthesis anticancer; Anti-tumor activities; Fraction of sp(3) carbon atoms (Fsp(3)); Phosphoinositide 3-kinase inhibitors; Thiazolo[5,4-d]pyrimidine; Thieno[2,3-d]pyrimidine.They researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Product Details of 4045-24-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4045-24-3) here.

As abnormal PI3K signaling is a feature of many types of cancer, the development of orally active PI3K inhibitors is of great significance for targeted cancer therapy. Through integrating strategies of reducing aromatic character/increasing the fraction of sp3 carbons together with scaffold hopping, we designed and synthesized two new series of thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives for use as PI3K inhibitors. Our structure-activity relationship studies led to the identification of thieno[2,3-d]pyrimidine 6a and thiazolo[5,4-d]pyrimidine 7a (I and II, resp.), which exhibited remarkable nanomolar PI3K potency, good antiproliferative activity, favorable pharmacokinetic properties and significant in vivo anti-cancer efficacy. Notably, thiazolo[5,4-d]pyrimidine 7a had better anti-cancer activity than thieno[2,3-d]pyrimidine 6a and is worthy of further pre-clin. evaluation for its use in cancer treatment.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Product Details of 4045-24-3 and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.An, Yang; Li, Yuke; Zhang, Xiao-Yan; Zhang, Zhe; Gou, Xue-Ya; Ding, Ya-Nan; Li, Qiao; Liang, Yong-Min researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Application In Synthesis of 4-Methoxypiperidine.They published the article 《Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation》 about this compound( cas:4045-24-3 ) in Organic Letters. Keywords: amino fused bicyclic compound preparation regioselective; iodoarene benzoyloxyamine norbornadiene Catellani reaction amination cyclization palladium catalyst. We’ll tell you more about this compound (cas:4045-24-3).

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2+3] or [2+4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates ortho-substituents that avoid a second C-H palladation. The scope of substrates was broad, o-methyl-substituted iodoarenes R-2-CH3-C6H3I (R = H, 4-F, 3-Me, 4-Cl, etc.), 3-iodo-4-methyl-pyridine were applied to the reaction smoothly, and o-phenyl-substituted iodoarenes 2-I-C6H4-(4-R1C6H4-) (R1 = H, Me, Ph, F, etc.), 1-(2-iodo-phenyl)-naphthalene can also be obtained by this method. In terms of mechanism, d. functional theory calculations proved the sequence of the key five-membered aryl-norbornene-palladacycle intermediate formation and C(sp3 or sp2)-H activation.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Application In Synthesis of 4-Methoxypiperidine and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Quality Control of 4-Methoxypiperidine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Amine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation. Author is Cao, Yanwei; Yang, Jian-Gong; Deng, Yi; Wang, Shengchun; Liu, Qi; Shen, Chaoren; Lu, Wei; Che, Chi-Ming; Chen, Yong; He, Lin.

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its use for the synergistic catalysis was enlightened. Study of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]- on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)sym. ureas and carbamates.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Quality Control of 4-Methoxypiperidine and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Sun, Yan; Fu, Rong; Lin, Songwen; Zhang, Jingbo; Ji, Ming; Zhang, Yan; Wu, Deyu; Zhang, Kehui; Tian, Hua; Zhang, Mingyi; Sheng, Li; Li, Yan; Jin, Jing; Chen, Xiaoguang; Xu, Heng published the article 《Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors》. Keywords: PI3K inhibitor thienopyrimidine thiazolopyrimidine synthesis anticancer; Anti-tumor activities; Fraction of sp(3) carbon atoms (Fsp(3)); Phosphoinositide 3-kinase inhibitors; Thiazolo[5,4-d]pyrimidine; Thieno[2,3-d]pyrimidine.They researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Product Details of 4045-24-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4045-24-3) here.

As abnormal PI3K signaling is a feature of many types of cancer, the development of orally active PI3K inhibitors is of great significance for targeted cancer therapy. Through integrating strategies of reducing aromatic character/increasing the fraction of sp3 carbons together with scaffold hopping, we designed and synthesized two new series of thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives for use as PI3K inhibitors. Our structure-activity relationship studies led to the identification of thieno[2,3-d]pyrimidine 6a and thiazolo[5,4-d]pyrimidine 7a (I and II, resp.), which exhibited remarkable nanomolar PI3K potency, good antiproliferative activity, favorable pharmacokinetic properties and significant in vivo anti-cancer efficacy. Notably, thiazolo[5,4-d]pyrimidine 7a had better anti-cancer activity than thieno[2,3-d]pyrimidine 6a and is worthy of further pre-clin. evaluation for its use in cancer treatment.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Product Details of 4045-24-3 and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.An, Yang; Li, Yuke; Zhang, Xiao-Yan; Zhang, Zhe; Gou, Xue-Ya; Ding, Ya-Nan; Li, Qiao; Liang, Yong-Min researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Application In Synthesis of 4-Methoxypiperidine.They published the article 《Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation》 about this compound( cas:4045-24-3 ) in Organic Letters. Keywords: amino fused bicyclic compound preparation regioselective; iodoarene benzoyloxyamine norbornadiene Catellani reaction amination cyclization palladium catalyst. We’ll tell you more about this compound (cas:4045-24-3).

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2+3] or [2+4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates ortho-substituents that avoid a second C-H palladation. The scope of substrates was broad, o-methyl-substituted iodoarenes R-2-CH3-C6H3I (R = H, 4-F, 3-Me, 4-Cl, etc.), 3-iodo-4-methyl-pyridine were applied to the reaction smoothly, and o-phenyl-substituted iodoarenes 2-I-C6H4-(4-R1C6H4-) (R1 = H, Me, Ph, F, etc.), 1-(2-iodo-phenyl)-naphthalene can also be obtained by this method. In terms of mechanism, d. functional theory calculations proved the sequence of the key five-membered aryl-norbornene-palladacycle intermediate formation and C(sp3 or sp2)-H activation.

When you point to this article, it is believed that you are also very interested in this compound(4045-24-3)Application In Synthesis of 4-Methoxypiperidine and due to space limitations, I can only present the most important information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Methoxypiperidine( cas:4045-24-3 ) is researched.Computed Properties of C6H13NO.Li, Meng; Wang, Dong-Hui published the article 《Copper-Catalyzed 3-Positional Amination of 2-Azulenols with O-Benzoylhydroxylamines》 about this compound( cas:4045-24-3 ) in Organic Letters. Keywords: azulenol benzoylhydroxylamine copper catalyst regioselective amination; aminoazulenol preparation. Let’s learn more about this compound (cas:4045-24-3).

A copper-catalyzed ortho-selective amination of 2-azulenols with O-benzoylhydroxylamines (RR’N-OBz) to synthesize ortho-aminoazulenols was reported. A wide range of functional groups on amines were compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields. The further synthetic elaboration using 3-amino-2-azulenols as starting materials was demonstrated.

As far as I know, this compound(4045-24-3)Computed Properties of C6H13NO can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem