With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40499-83-0,Pyrrolidin-3-ol,as a common compound, the synthetic route is as follows.
To a reaction flask were added compound 11 (30 mg, 0.075 mmol) and (R)-3-hydroxypyrrolidine (7.86 mg, 0.09 mmol), 2 mL isopropyl alcohol was added, followed by DIPEA (21.32 mg, 0.165 mmol), and the reaction was heated to 140 C and stirred for 2 hours. The reaction was cooled to room temperature, concentrated to remove solvent, purified by silica gel column chromatography to afford 27.3 mg of a product, yield: 81%. LC-MS(APCI): m/z = 451.5(M+1)+; 1H NMR (400 MHz, DMSO) delta 10.22 (s, 1H), 8.75 (d, J = 2.4 Hz, 1H), 8.25 (s, 1H), 8.07 (d, J = 2.3 Hz, 1H), 7.89 (d, J = 9.1 Hz, 2H), 7.31 (d, J = 8.9 Hz, 2H), 4.81 (s, 1H), 4.14 (s, 1H), 3.50 – 3.42 (m, 1H), 3.23 – 3.14 (m, 2H), 2.80 (d, J = 11.8 Hz, 1H), 1.79 (dd, J = 8.9, 4.4 Hz, 1H), 1.73 – 1.63 (m, 1H).
40499-83-0, 40499-83-0 Pyrrolidin-3-ol 98210, apyrrolidine compound, is more and more widely used in various fields.
Reference£º
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (51 pag.)EP3553057; (2019); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem