Category: 50609-01-3

50609-01-3,50609-01-3, 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound (9a) (0.89 g, 4.6 mmol), DMAP (0.24 g), and EDCI (1.46 g, 7.6 mmol) were added in sequence to a solution of (6) (1.16 g, 3.8 mmol) in anhydrous THF (100 mL). An excess of triethylamine (5 mL) was added dropwise and the mixture was stirred at room temperature for 8 h. Then the reaction mixture was quenched with water and extracted with EtOAc. The combined organic layers were washed with HCl (1 M), brine, saturated NaHCO3 solution and dried over Na2SO4. After filtration and concentration of the organic phase, crude (10) (1.19 g, 65%) was obtained. To a solution of (10) (1.19 g, 2.47 mmol) in methanol (60 mL) was added Pd/C (0.20 g), stirred for 24 h at room temperature under the atmosphere of hydrogen. The mixture was filtered to remove Pd/C, and the residue was purified by column chromatography yielding (17a) (0.92 g, 95%) as a white solid.

50609-01-3 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline 6493749, apyrrolidine compound, is more and more widely used in various fields.

Reference£º
Article; Lu, Wen; Li, Pengfei; Shan, Yuanyuan; Su, Ping; Wang, Jinfeng; Shi, Yaling; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 1044 – 1054;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50609-01-3,4-(2-(Pyrrolidin-1-yl)ethoxy)aniline,as a common compound, the synthetic route is as follows.

To a round bottom flask was added 6-chloro-4- (S) – (tetrahydrofuran-2-yl) methylaminopyrimidine (0.1 g, 0.468 mmol)And 4- (2- (pyrrolidin-1-yl) ethoxy) aniline (0.088 mL, 0.468 mmol) was dissolved in 2-methoxyethanol (5 mL), a hydrochloric acid solution (4M dioxane solution, 0.1 mL) was added, and the mixture was stirred at 110 DEG C for 24 hours. When the reaction was completed, the solvent was removed by distillation under reduced pressure, and a saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture, followed by extraction with dichloromethane. After drying over anhydrous magnesium sulfate, the solvent was removed by distillation under reduced pressure, and the resultant product was purified by column chromatography to obtain the title compound (0.095 g, 53%)., 50609-01-3

As the paragraph descriping shows that 50609-01-3 is playing an increasingly important role.

Reference£º
Patent; Korea Institute of Science and Technology; Lee So-ha; Ryu Gyeong-ho; Kim Tae-yeong; Ho Seu-ni-al-ri-, -e-seu-ram-mo-ha-me-deu; (27 pag.)KR101916773; (2018); B1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem