Category: 5264-35-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.,5264-35-7

General procedure: The title compounds were synthesized according to the literature [25]. A mixture of diketone 1a or 1b (234 mmol), corresponding lactim-methylethers (258 mmol) and a catalytic amount of nickel(II) acetylacetonate (0.59 g, 2.3 mmol)was heated at 100 ¡ãC for 24 h. Then the reaction mixture was cooled. The solid products were filtered and crystallized. (In the case of 3e and 4b, water (170 mL) was added and the reaction mixture was extracted with dichloromethane (3 x 90 mL). The combined organic layers were dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the crude product. The crude product was purified chromatographically on silica gel.) The compounds prepared according to the procedure are summarised in Supplementary material.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Josefi?k, Frantis?ek; Svobodova?, Marke?ta; Bertolasi, Valerio; S?imu?nek, Petr; MacHa?c?ek, Vladimi?r; Almonasy, Numan; C?ernos?kova?, Eva; Journal of Organometallic Chemistry; vol. 699; (2012); p. 75 – 81;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5264-35-7, To a solution of N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[3-carbamoyl-4-(piperidin-4-yloxy)phenyl]methanesulfonamide dihydrochloride (0.95 g) obtained in example 101(a) in ethanol (15 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole (0.52 g), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (1.20 ml) at room temperature, and the resulting mixture was allowed to stand at room temperature overnight, and at the end of this time, 5-methoxy-3,4-dihydro-2H-pyrrole (0.17 g) and triethylamine (0.24 ml) were furthermore added successively, and the resulting mixture was stirred at room temperature for 6 hours and then evaporated in vacuo. Subsequently, to the residue obtained were added successively ethanol (10 ml) and a 4N solution of hydrogen chloride in dioxane (4 ml), and the resulting mixture was evaporated in vacuo. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 10 percent acetonitrile/water). The amorphous solid obtained was dissolved in 1N hydrochloric acid (5 ml), and the resulting mixture was evaporated to dryness in vacuo. The residue obtained was dissolved in water and then lyophilized to afford the title compound (0.67 g, yield: 63 percent) as a colorless amorphous solid. 1H NMR (400MHz, DMSO-d6) delta ppm : 1.79-1.92 (2H, m), 2.02-2.14 (4H, m), 2.99 (2H, t, J=8.0), 3.37 (3H, s), 3.41-3.58 (4H, m), 3.82-3.90 (2H, m), 4.46 (2H, d, J=6.0), 4.86 (1H, m), 6.47 (1H, dt, J=16.0, 6.0), 6.59 (1H, d, J=16.0), 7.26 (1H, d, J=9.0), 7.49-7.58 (2H, m), 7.67-7.77 (3H, m), 7.91 (1H, s) ; IR (KBr, cm-1) : 1669, 1334, 1151.

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5-methoxy-3,4-dihydro-2H-pyrrole (0.3 mL) was added to the solution of 5-propyl-8- [(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole tetraTFA salt (110 mg, 138 mg) in methanol (1 mL) at room temperature. The EPO mixture was stirred at room temperature overnight and purified by preparative HPLC (10-70percent CH3CN) to afford the title compound as its TFA salt (31mg). MS (M+l): 407.1. 1H NMR (400 MHz, CD3OD) delta ppm 0.91 (t, J=7.42 Hz, 3 H), 0.99 (d, J=6.44 Hz, 3 H), 1.06 – 1.28 (m, 2 H), 1.55 – 1.89 (m, 5 H), 2.14 – 2.39 (m, 2 H), 2.89 (s, 1 H), 3.00 – 3.21 (m, 4 H), 3.67 – 3.92 (m, 3 H), 3.94 – 4.06 (m, 2 H), 4.08 – 4.18 (m, 2 H), 4.60 (s, 1 H), 4.79 – 4.89 (m, 2 H), 7.17 – 7.27 (m, 1 H), 7.41 – 7.60 (m, 2 H)., 5264-35-7

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca AB; WO2006/101434; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5264-35-7, Step A: Preparation of 3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1) To a stirred solution of 3,4-dihydro-5-methoxy-2H-pyrrole (5.00 g, 50.43 mmol) in ethanol (30 mL) was added ammonium chloride (2.68 g, 50.43 mmol). The reaction mixture was stirred at room temperature for 24 h. The organic layer was then concentrated under reduced pressure to afford the title product as a white solid (6.0 g), which was used without further purification in the next step.

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; US2010/99561; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem