578-95-0, Name is Acridin-9(10H)-one, molecular formula is C13H9NO, belongs to pyrrolines compound, is a common compound. In a patnet, author is Lu, Yi, once mentioned the new application about 578-95-0, Product Details of 578-95-0.
A new process for the synthesis of nafoxidene as a key intermediate of lasofoxifene
A novel brief process for the synthesis of nafoxidene has been developed. The epoxidation of 6-methoxy-1-{4-[2-(pyrrolin-1-yl)ethoxy)]phenyl}-3,4-dihydronaphthalene by m-CPBA directly gave the ketone 6-methoxy-1-[4-(2-(pyrrolidin-1-yl)ethoxy) phenyl]-3,4-dihydronaphthalen-2(1H)-one, which was subject to phenyl magnesium bromide/cerium chloride and subsequently treated with an acid to yield nafoxidene. In addition, the preparation of the starting naphthalene was also optimized by replacing the aromatic lithium at low temperature with its Grignard reagent at refluxing THF. This mild process, without the use of toxic or noble metals, was more cost-efficient and easily worked up.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem