Category: 58081-05-3

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.HPLC of Formula: 58081-05-3.Zhang, Yang; Xia, Yihong; Lai, Yongji; Tang, Fang; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Zhang, Yonghui; Zhang, Jinwen published the article 《Efficient synthesis of kinsenoside and goodyeroside A by a chemo-enzymatic approach》 about this compound( cas:58081-05-3 ) in Molecules. Keywords: kinsenoside chemoenzymic synthesis; goodyeroside chemoenzymic synthesis. Let’s learn more about this compound (cas:58081-05-3).

Kinsenoside (1) and goodyeroside A (2), two naturally occurring stereoisomers with diverse biol. activities, have been synthesized efficiently by a chemo-enzymic approach with a total yield of 12.7%. The aglycons, (R)- and (S)-3-hydroxy-γ-butyrolactone, were prepared from d- and l-malic acid by a four-step chem. approach with a yield of 75%, resp. These butyrolactones were then successfully glycosidated using β-D-glucosidase as a catalyst in a homogeneous organic-water system. Under the optimized enzymic conditions, the yields of kinsenoside and goodyeroside A in the enzymic steps both reached 16.8%.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)HPLC of Formula: 58081-05-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 58081-05-3, is researched, Molecular C4H6O3, about Production of (S)-4-chloro-3-hydroxybutyrate by microbial resolution using hydrolase from Rhizobium sp. DS-S-51, the main research direction is Rhizobium chlorohydroxybutyrate sequence stereoselective reduction.Application of 58081-05-3.

(S)-4-Chloro-3-hydroxybutyrate (CHB) is essential for the synthesis of biol. and pharmacol. important compounds Rhizobium sp. DS-S-51 isolated from soil samples showed hydrolytic activity toward (R)-CHB in the racemate to (R)-3-hydroxy-γ-butyrolactone (HL) under a simple composition of the reaction. Residual (S)-CHB was obtained with high optical purity. The gene encoding the enzyme concerned, designated CHB hydrolase, was isolated from DS-S-51, and the gene was highly expressed in Escherichia coli JM109. When the resolution of racemic Me CHB (CHBM) as a substrate was performed using this recombinant cell, JM109 (pKK-R1), the hydrolytic activity was found to be 40-fold greater than that of DS-S-51, and the maximum concentration of the substrate added increased 2-fold. Moreover, (R)-HL was also obtained without decreasing the optical purity compared with that when (R)-CHBM was used as a substrate.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Application of 58081-05-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Chen, Xuesong; Wu, Yu-Lin; Chen, Dihua published an article about the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3,SMILESS:O=C1OC[C@H](O)C1 ).Product Details of 58081-05-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:58081-05-3) through the article.

A new cerebroside, typhoniside A (I), with C18-4,8-sphingadienine as the long-chain base, has been isolated from the traditional Chinese medicine Typhonium giganteum Engl., and its structure was determined by 2D-NMR and MS methods. It was then synthesized using D-xylose and ascorbic acid as the chiral starting materials.

《Structure determination and synthesis of a new cerebroside isolated from the traditional Chinese medicine Typhonium giganteum Engl.》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Product Details of 58081-05-3.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB, published in 1990, which mentions a compound: 58081-05-3, mainly applied to hydroxybutanolide ring cleavage iodotrimethylsilane; iodohydrin cyclization silver oxide; epoxy ester preparation alkylation cuprate; hydroxy ester, Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.

The preparation of enantiomerically pure β,γ-epoxy esters was achieved by chemoselective opening of β-hydroxybutanolides with Me3SiI followed by cyclization of the resulting iodohydrins with Ag2O. The reaction of these epoxy esters with lithio- or magnesiocuprates afforded stereochemically pure α-substituted-β-hydroxy esters. Alternatively, the title compound, (R)-H2NCH2CH(OH)CH2CO2H, was synthesized in optically pure form from the iodohydrin (R)-ICH2CH(OH)CH2CO2Et.

《Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about A modular approach to marine macrolide construction. 2. Concise stereocontrolled synthesis of the C17-C28 (CD) spiroacetal component. Author is Paquette, Leo A.; Braun, Alain.

The CD spiroacetal ring system (I) of altohyrtin A, which houses one-fifth of the stereogenic centers resident in the macrolide, has been synthesized through a combination of aldol condensations having different stereocontrol elements.

《A modular approach to marine macrolide construction. 2. Concise stereocontrolled synthesis of the C17-C28 (CD) spiroacetal component》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A novel synthesis of (R)- and (S)-4-hydroxytetrahydrofuran-2-ones, published in 1987-06-30, which mentions a compound: 58081-05-3, mainly applied to furanone hydro hydroxy chiral; hydroxy lactone chiral; butanolide hydroxy chiral; dioxolaneacetate methyl; dioxaspirodecaneacetate chiral; spirodioxadecaneacetate chiral, SDS of cas: 58081-05-3.

The hydroxy ester I (R = H, R1 = OH), prepared from L-ascorbic acid by sequential treatment with acetone and AcCl, 30% H2O2 and CaCO3, and Me2SO4, was treated with MeSO2Cl and pyridine in CH2Cl2 to give 90% I (R = H, R1 = MeSO3), which, when heated at 85° with LiCl in DMF furnished a mixture of the erythro and threo chloro esters I (R = Cl, R1 = H; R = H, R1 = Cl) (II). Upon hydrogenolysis with 10% Pd/C in the presence of Et3N, II yielded the ester I (R = R1 = H), which was treated with dilute HCl giving a nearly quant. yield of hydroxylactone III. The (S)-enantiomer was analogously prepd from D-isoascorbic acid.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)SDS of cas: 58081-05-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Formula: C4H6O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones.

A new total synthesis of the bioactive compounds, kinsenoside (I; R1 = H) and goodyeroside A (II; R2 = H), has been accomplished from readily available starting materials. The chiral 2(5H)-furanone III and its enantiomer IV were employed as the key chiral intermediates to construct the chiral glycosides V and VI with the appropriate stereochem. The spectral data of the target compounds and their acetylated derivatives (I; R1 = Ac) and (II; R2 = Ac) are identical with those of the natural and corresponding acetylated products.

《A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Formula: C4H6O3.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Ishibashi, Fumito; Hayashita, Mami; Okazaki, Momotoshi; Shuto, Yoshihiro published the article 《Improved procedure for the enantiomeric synthesis of 1-hydroxy/acetoxy-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans: total syntheses of (+)-paulownin, (+)-phrymarin I and (+)-phrymarin II》. Keywords: lignan paulownin phrymarin enantiomeric synthesis photocyclization.They researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Electric Literature of C4H6O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:58081-05-3) here.

Short enantiomeric syntheses of the 1-hydroxy/acetoxy-3,7-dioxabicyclo[3.3.0]octane lignans, (+)-paulownin (I, R1 = R2 = R3 = H), and (+)-phrymarin I (I, R1 = R2 = OMe, R3 = Ac) and II (I, R1 = OMe, R2 = H, R3 = Ac), were accomplished by starting from the chiral synthon, (R)-(+)-3-hydroxybutanolide, and employing photocyclization as the key step.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Electric Literature of C4H6O3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Application In Synthesis of (R)-4-Hydroxydihydrofuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of a new cerebroside isolated from Typhonium giganteum Engl. Author is Chen, Xue-Song; Wu, Yu-Lin; Chen, Di-Hua.

The stereoselective synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4, 8-sphingadienine, α-hydroxy acid and a saccharide head. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a SN2 type reaction. α-Hydroxy acid was prepared from (R)-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from L-ascorbic acid.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Application In Synthesis of (R)-4-Hydroxydihydrofuran-2(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of nature product kinsenoside analogues with anti-inflammatory activity, published in 2021-01-01, which mentions a compound: 58081-05-3, mainly applied to kinsenoside analog preparation antiinflammatory structure activity; goodyeroside A analog preparation antiinflammatory structure activity; Anti-inflammatory; Goodyeroside A; Kinsenoside; Nitric Oxide Release; Structure-activity Relationship, COA of Formula: C4H6O3.

Kinsenoside (I) is a major bioactive component in herbal medicines that possesses a broad range of pharmacol. functions. Goodyeroside A (II), an epimer of kinsenoside, remains less explored. In this report, the authors chem. synthesized kinsenoside, goodyeroside A and their analogs with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart III demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppress inflammation through inhibiting the NF-κB signal pathway effectively. The structure-activity relationship is also explored for further development of more promising kinsenoside analogs as drug candidates.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)COA of Formula: C4H6O3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem