Category: 63468-63-3

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.63468-63-3, name is 2,5-Dihydro-1H-pyrrole hydrochloride. Here is a downstream synthesis route of the compound 63468-63-3. 63468-63-3

63468-63-3, To a solution of 2,5-dihydro-lH-pyrrole hydrochloride (12 g, 0.11 mol) in H2O (100 niL) was added EtOAc (100 niL) and K2CO3 (89 g, 0.64 mol). The mixture was stirred at RT for 30 min. Cbz-Cl (22 g, 0.13 mol) was added dropwise at 0C and the mixture was stirred for 1 h. The organic layer was separated and the aqueous layer was extracted with EtOAc (3×20 mL). The combined organic layers were dried over Na2SO4. The solvent was removed in vacuo to afford the crude product (25 g, 95%), as a light oil, which was carried directly to the next step.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 63468-63-3

Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

63468-63-3, 2,5-Dihydro-1H-pyrrole hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63468-63-3, 2,5-Dihydropyrrole hydrochloride (0.75 g, 7.104 mmol) and sodium dicyanamide (0.63 g, 7.104 mmol) were dissolved in a butanol (20 mL) solution, and then stirred for 3 hours under reflux. After completion of the reaction was confirmed, sodium chloride formed by filtering the reaction mixture was removed, and the filtrate was then concentrated at a reduced pressure. The concentrate was dissolved in methanol (2 mL), and ethyl acetate (5 mL) was then added thereto, and stirred at room temperature for an hour. The formed solid was filtered and the filtrate was washed with ethyl acetate (2×20 mL). The filtrate was dried at a reduced pressure to obtain a white solid target compound (0.90 g, 93%).1H NMR (600 MHz, CD3OD) delta 5.89 (m, 2H), 4.16 (m, 4H); LC-MS m/z 137.2 [M+1]+

The synthetic route of 63468-63-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HANALL BIOPHARMA CO., LTD.; MIN, Chang Hee; KIM, Yong Eun; OH, Byung Kyu; LEE, Ji Sun; HEO, Hye Jin; OH, Ju Hoon; CHO, Woong; WO2014/123364; (2014); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63468-63-3,2,5-Dihydro-1H-pyrrole hydrochloride,as a common compound, the synthetic route is as follows.

63468-63-3, To a solution of 2,5-dihydro-lH-pyrrole hydrochloride (12 g, 0.11 mol) in H2O (100 niL) was added EtOAc (100 niL) and K2CO3 (89 g, 0.64 mol). The mixture was stirred at RT for 30 min. Cbz-Cl (22 g, 0.13 mol) was added dropwise at 0C and the mixture was stirred for 1 h. The organic layer was separated and the aqueous layer was extracted with EtOAc (3×20 mL). The combined organic layers were dried over Na2SO4. The solvent was removed in vacuo to afford the crude product (25 g, 95%), as a light oil, which was carried directly to the next step.

As the paragraph descriping shows that 63468-63-3 is playing an increasingly important role.

Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem