Downstream synthetic route of 66673-40-3

The synthetic route of 66673-40-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66673-40-3,(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone,as a common compound, the synthetic route is as follows.,66673-40-3

(S)-5-(3-(1-(4-hexylphenyl)-5-oxopyrrolidin-2-yl)propyl)thiophene-2-carboxylic acid 2-hydroxyethyl ester (3); Step 1. Arylation of 4 to Give 5Copper (I) iodide (106 mg, 0.56 mmol) and N,N’-dimethylethylenediamine (120 muL, 1.11 mmol) were added in rapid succession to a mixture of (R)-5-(hydroxymethyl)pyrrolidin-2-one (4, 776 mg, 6.74 mmol), 1-bromo-4-n-hexylbenzene (1.34 g, 5.56 mmol) and potassium carbonate (1.53 g, 11.07 mmol) in acetonitrile (12.6 mL). The mixture was heated at reflux. After 3 days, the mixture was cooled to room temperature, diluted with EtOAc (100 mL), and filtered through celite, washing with excess EtOAc. The filtrate was concentrated in vacuo. Purification of the residue by chromatography on 120 g silica gel (hexanes?EtOAc, gradient) afforded 960 mg (63%) of compound 5.

The synthetic route of 66673-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Old, David W.; US2009/192159; (2009); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem