Category: 7544-75-4

Analyzing the synthesis route of 7544-75-4

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

7544-75-4, 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7544-75-4, 2-Phenyl-6,7-dihydro-5H-pyrrolo[1, 2-a] imidazole; Combine 2-iminopyrrolidine hydrochloride (6. 98 g, 57. 8 mmol) (Callahan, et al., (at) J. Med. Chem. 45, 999-1001 (2002)), 2-bromoacetophenone (3. 8 g, 19. 3 mmol), and sodium carbonate (8. 2 g, 77. 2 mmol) in dry dimethylformamide (25 mL). Heat at 80C for 18 hours. Cool to room temperature, add water (60 mL), and extract with ethyl acetate (3 x 100 mL). Concentrate the combined organic layers under reduced pressure. Dilute the residue with diethyl ether (100 mL), wash with cold water (3 x 80 mL), and concentrate under reduced pressure to provide the desired compound as a white solid (3. 2 g, 89 %). MS (ES) : m/z = 185. 1 (M++H)

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/80380; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Brief introduction of 7544-75-4

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.

7544-75-4, 1) 7,8-Dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione In the manner described in Example 1–1), the entitled compound was obtained as colorless crystals from 2-iminopyrrolidine hydrochloride and phenoxycarbonylisocyanate. Melting Point: 201-202 C. NMR Spectrum (DMSO-d6): 2.87 (2H, t), 2.07 (2H, t), 3.82 (2H, t), 11.25 (1H, bs) IR Spectrum nu (KBr) cm-1: 3430, 3210, 3080, 1740, 1710, 1690, 1630, 1440, 1410

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Pharmaceutical Co., Ltd.; US5232924; (1993); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Simple exploration of 7544-75-4

7544-75-4 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride 12778905, apyrrolines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.

Prepare 2-iminopyrrolidine hydrochloride (6. 98 g, 57.8 mmol) according to Callahan, et al., J. Med. Chem. 2002,45, 999-1001) and combine 2-bromoacetophenone (3.8 g, 19.3 mmol) with Na2CO3 (8.2 g, 77.2 mmol) in dry DMF (25 [ML)] and heat at [80C] for 18 hours. Then, cool the mixture to room temperature, add water (60 mL), and extract with EtOAc (3 x 100 mL). Concentrate the combined organic layers in vacuo, dilute the residue with ether (100 mL), and wash with cooled water (3 x 80 mL). Concentrate the organic layer in vacuo to give a white solid, 3.2 g, 89 [%] yield. MS [(ES+)] : [IIZLZ] = 185. 1 [(M+H) +], 7544-75-4

7544-75-4 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride 12778905, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/14900; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

New learning discoveries about 7544-75-4

As the paragraph descriping shows that 7544-75-4 is playing an increasingly important role.

7544-75-4, 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) A DMA (35 ml) suspension containing Compound 1 (5.57 g, 28 mmol), Compound 2 (10 g, 83 mmol) and sodium carbonate (12 g, 113 mmol) was stirred at 80 C. for 15 hours under argon atmosphere. After cooling by allowing to stand, the reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over anhydrous sodium sulfate, and then, concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (hexane:ethyl acetate=3:2) to give Compound 3 (2.02 g, 11 mmol, 39%) as a solid.

As the paragraph descriping shows that 7544-75-4 is playing an increasingly important role.

Reference£º
Patent; Kusama, Mari; Watanabe, Tatsuya; Hosaka, Toshihiro; Kubota, Yuko; US2008/9506; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem