Category: 78648-27-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78648-27-8,2-(Pyrrolidin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.,78648-27-8

1- [3- (DIMETHYLAMINO) PROPYL]-3-ETHYLCARBODIIMIDE (0.19 g) was added to a solution of 1- (2-PYRIDINYLACETYL)-5- indolinamine (0.25 g), 2- (1-PYRROLIDINYL) benzoic acid (0.23 g), 1-hydroxybenzotriazole hydrate (0.16 g) and 4- dimethylaminopyridine (6 mg) in N, N-dimethylformamide (5 ml) under ice-cooling and the mixture was stirred at ambient temperature for 18 hours. The reaction mixture was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with ethyl acetate to give N- [1- (2-PYRIDINYLACETYL)-2, 3- DIHYDRO-LH-INDOL-5-YL]-2- (L-PYRROLIDINYL) benzamide (0.27 g). 1H-NMR (DMSO-d6): 8 1. 75-1. 95 (4H, m), 3.08-3. 29 (4H, m), 3.16 (2H, t, J=8.4 Hz), 4.00 (2H, s), 4.21 (2H, t, J=8.4 Hz), 6.65-6. 82 (2H, m), 7.21-7. 47 (5H, m), 7.69 (1H, s), 7.76 (1H, dt, J=1.8 Hz, 7.6 Hz), 7.96 (1H, d, J=8.7 Hz), 8.50 (1H, dd, J=0.9 Hz, 4.2 Hz), 10.27 (1H, s) (-) ESI-MS: 425 (M-H)-

The synthetic route of 78648-27-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; DAISO CO., LTD.; WO2004/39795; (2004); A2;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

78648-27-8, 2-(Pyrrolidin-1-yl)benzoic acid is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of aromatic acid (1 equiv., 0.2 mmol), Co(OAc)2 (0.1 equiv., 0.02mmol), (D, L)-tyrosine (0.15 equiv., 0.03 mmol) were dissolved in CH3CN (5mL), and stirred at 25 oC, then 1 atm of O2 was bubbled into the system for 10h. After the reaction finished, the solvent was evaporated under vacuum and purified by column chromatography to afford the desired product., 78648-27-8

78648-27-8 2-(Pyrrolidin-1-yl)benzoic acid 12707331, apyrrolidine compound, is more and more widely used in various fields.

Reference£º
Article; Shang, Xiao-Jie; Liu, Zhong-Quan; Tetrahedron Letters; vol. 56; 2; (2015); p. 482 – 484;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem