Category: 872-32-2

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, To an ice-cooled mixture of Compound I (5.0 g) and THF (150 mL) was added NCS (64.2 g), and the mixture was stirred at 55¡ãC for 1 hour. To the reaction mixture was added water, and the mixture was extracted with hexane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give Compound II.

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Dainippon Sumitomo Pharma Co., Ltd.; HORIUCHI, Yoshihiro; FUJIWARA, Hiroaki; SUDA, Hitoshi; SASAKI, Izumi; IWATA, Mitsutaka; SAWAMURA, Kiyoto; EP2612848; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, 5-Methyl-3,4-dihydro-2H-pyrrole (1.00 g, 12.0 mmol) was dissolved in carbon tetrachloride. To the solution was added NCS (12.85 g, 96 mmol) as a solid and reaction mixture heated to 85 0C and stirred overnight. The mixture was cooled to 0 0C and the precipitate filtered off and the solvent evaporated. The residue was dissolved in methanol and sodium methoxide (3.90 g, 72.2 mmol) was added. The resulting suspension was heated to reflux and stirred for 3 h. The methanol was evaporated and the residue suspended in Et20. The solid was filtered off and the ether evaporated. The residue was dissolved in DCM and 2M HCI was added. The biphasic solution was stirred until no SM remained. The phases were separated and the organic layer was dried over MgSO4 and evaporated to an orange oil. The crude oil was adsorbed onto silica and run on 40 g of silica with EtOAc and Hexanes to afford the title compound as an orange solid (0.2958 g, 1.854 mmol, 15.41 percent yield). 1H NMR (400 MHz, CDCI3): delta ppm 9.54 (br. s., 1 H), 6.80 (s., 1 H), 6.17 (s., 1 H), 3.83 (s, 3 H). MS: m/z 160.0 (M+1 ).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: To a solution of i-Pr2NH (1.52 g, 2.1 mL, 15 mmol, 1.5 equiv) in anhyd THF (20 mL) was added n-BuLi (6 mL, 15 mmol, 1.5 equiv, 2.5 M in hexane) via a syringe at 0 ¡ãC under a nitrogen atmosphere, and the resulting solution was stirred for 30 min at 0 ¡ãC. Subsequently, 2-methyl-1-pyrroline (1; 0.83 g, 0.95 mL, 10 mmol, 1 equiv) was added via a syringe at 0 ¡ãC and the resulting solution was stirred for 1 h at 0 ¡ãC. Then, a solution of 1-benzyl-2-(bromomethyl)aziridine (2, R = Ph;8 2.25 g, 10 mmol, 1 equiv) in THF (10 mL) was added via a syringe at 0 ¡ãC and the resulting solution was stirred for 17 h at r.t. Afterwards, the reaction mixture was poured into H2O (50 mL) and extracted with Et2O (3 ¡Á 50 mL). Drying (MgSO4), filtration of the drying agent, and evaporation of the solvent in vacuo furnished 3a as an orange oil; yield: 2.12 g (9.3 mmol, 93percent). Because of the high purity of the obtained aziridines 3 (purity >95percent, 1H NMR), these compounds were used as such in the next step.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Dolfen, Jeroen; D?hooghe, Matthias; Synthesis; vol. 49; 10; (2017); p. 2215 – 2222;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.,872-32-2

General procedure: Acyl chloride (1.2 mmol, 1.2 equiv) was added to a solution of 4-dimethylaminopyridine (DMAP) (1.2 mmol, 1.2 equiv) in acetonitrile (1.0 mL) at 0 ¡ãC. The reaction was stirred at room temperature for 15 min. A solution of the 5-methyl-3,4-dihydro-2H-pyrrole (1.0 mmol) in acetonitrile (1.0 mL) was added and the reaction was stirred at room temperature for 3 h. p-Toluenesulfonic acid monohydrate (3.0 mmol, 3.0 equiv) was added at 0 ¡ãC under inert atmosphere. The reaction was then stirred at room temperature for 2 h. Arylhydrazine (1.5 mmol, 1.5 equiv) was added and stirred for an addition 5 min at room temperature. The reaction was then heated to 82 ¡ãC for 20 h. The reaction cools down to room temperature. The residue was then dissolved in ethyl acetate and washed with brine and a saturated aqueous solution of NaHCO3. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude solid, which was purified by column chromatography on silica gel.

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang; Tetrahedron; vol. 68; 3; (2012); p. 813 – 818;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, General procedure: General protocol for the preparation of alkynyl imines Ml-6. percent [0070] To a solution of freshly distilled diisopropylamine (6.5 mmol, 0.93 mL) in anhydrous THF (10 mL) at 0 ¡ãC was added slowly a solution of “butyllithium (1.6 M in hexanes, 3.75 mL, 6.0 mmol, 1.2 equiv.) under argon atmosphere. After 20 min this solution was cooled to -78 ¡ãC and a solution of cyclic imine 3 (5.0 mmol) in anhydrous THF (5.0 mL) was added dropwise. The resulting mixture was then stirred at -78 ¡ãC for 2 h. A solution of alkyl iodide 4 (6.0 mmol, 1.2 equiv.) in anhydrous THF (5.0 mL) was added slowly, after which the reaction mixture was slowly warmed to 23 ¡ãC and stirred overnight. An aqueous solution of sodium hydroxide (0.5 M, 20 mL) was then added and the aqueous layer was extracted with ether. The combined organic phases were washed with a solution of sodium hydroxide (0.5 M), dried over anhydrous Na2S04. After filtration, the solvent was removed in vacuo to give the residue, which was used in the next step without further purification.

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; THE REGENTS OF THE UNIVERISITY OF COLORADO, A BODY CORPORATE; WANG, Xiang; PODOLL, Jessica; CHANG, Le; WO2014/165548; (2014); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

General procedure: To a stirred suspension of urea hydrogen peroxide (UHP) (1.411 g, 15 mmol) in MeOH (10 mL), methyltrioxorhenium (MTO) (6.2 mg, 0.5 molpercent) was added. Within 15 min the yellow color appeared, the reaction mixture was cooled in an ice bath at -2 ¡ãC and the imine 7 or amine 8, 9 (5 mmol) was then added dropwise via syringe over 30 min. After completion of the addition, the reaction was warmed up to 20 ¡ãC. Another three portions of MTO (6.2 mg, 0.5 molpercent) were added at 30 min intervals. After each addition, the reaction mixture developed a yellow color, which then disappeared. The resulting solution was stirred at 20 ¡ãC until disappearance of the starting material (TLC control). After removal of the solvent under reduced pressure, the residue was diluted with CH2Cl2 and the undissolved urea filtered off. Removal of the solvent afforded the crude product, which was purified by flash column chromatography on neutral alumina. The product was found to be unstable, but it could be stored for several days at -30 ¡ãC under Ar atmosphere. 2-Methyl-1-pyrroline N-oxide (2b). Yield: 0.43 g, 87 percent. CH2Cl2-MeOH 200:1. 1H NMR (600 MHz, CDCl3, 298K): delta = 3.96 (m, 2H, N-CH2), 2.69 (m, 2H, CH2), 2.06 (m, 2H, CH2), 1.99 (s, 3H, CH3). 13C NMR (151 MHz, CDCl3, 298K): delta = 144.8 (C=N), 62.0 (N-CH2), 33.0 (CH2), 16.6 (CH2), 12.6 (CH3).

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Zhu, De-Ping; Xu, Bao-Hua; Du, Yi-Ran; Zhang, Suo-Jiang; Tetrahedron; vol. 74; 18; (2018); p. 2230 – 2238;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-methyl-1-pyrroline (2.8 g, 33.7 mmol) and the corresponding cyclic phosphite 2a-2e (30.6 mmol) were stirred in toluene (5 mL) for 4-6 h at room temperature (conversion was checked by TLC or 31P NMR), the mixture was poured into 30 mL water, slowly acidified to pH 3 with 11 N HCl then quickly extracted with tert-butyl methyl ether (TBME) (3 .x. 20 mL). The aqueous phase was basified to pH 9-10 with NaOH pellets then extracted with CH2Cl2 (4 .x. 20 mL). The combined organic phases were dried over MgSO4, filtered and roto-evaporated to give the crude aminophosphonates 3a-3e as white powders which were then purified by SiO2 column chromatography with eluent CH2Cl2/EtOH 8/1., 872-32-2

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gosset, Gae?lle; Cle?ment, Jean-Louis; Culcasi, Marcel; Rockenbauer, Antal; Pietri, Sylvia; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2218 – 2230;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.,872-32-2

General procedure: Acyl chloride (1.2 mmol, 1.2 equiv) was added to a solution of 4-dimethylaminopyridine (DMAP) (1.2 mmol, 1.2 equiv) in acetonitrile (1.0 mL) at 0 ¡ãC. The reaction was stirred at room temperature for 15 min. A solution of the 5-methyl-3,4-dihydro-2H-pyrrole (1.0 mmol) in acetonitrile (1.0 mL) was added and the reaction was stirred at room temperature for 3 h. p-Toluenesulfonic acid monohydrate (3.0 mmol, 3.0 equiv) was added at 0 ¡ãC under inert atmosphere. The reaction was then stirred at room temperature for 2 h. Arylhydrazine (1.5 mmol, 1.5 equiv) was added and stirred for an addition 5 min at room temperature. The reaction was then heated to 82 ¡ãC for 20 h. The reaction cools down to room temperature. The residue was then dissolved in ethyl acetate and washed with brine and a saturated aqueous solution of NaHCO3. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude solid, which was purified by column chromatography on silica gel.

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang; Tetrahedron; vol. 68; 3; (2012); p. 813 – 818;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, 5-methyl-3,4-dihydro-2H-pyrrole (4 g, 0.05 mol) was dissolved in THF (120 mL) and N-chlorosuccinimide (51.4 g, 0.39 mol) was slowly added at 0 ¡ã C and refluxed for 15 minutes. The reaction mixture was stirred at 70 & lt; After stirring for two and a half hours, the THF was removed under reduced pressure, extracted three times with dichloromethane and washed with brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed under reduced pressure to obtain 4,4-dichloro-5- (trichloromethyl) -3,4-dihydro-2H-pyrrole.It was used immediately for the next reaction without further purification. 4,4-Dichloro-5- (trichloromethyl) -3,4-dihydro-2H-pyrrole (2 ) (12 g, 0.05 mol) To methanol (100 mL) was added And dissolved in sodium methoxide (NaOMe) (28 wtpercent methanol) (16 g, 0.29 mol) is slowly added dropwise at 0 . The reaction mixture was reacted at room temperature for 2 hours, extracted three times with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The reaction mixture was purified by flash column chromatography (n-hexane: ethyl acetate = 5: 1) Purification yielded 6.5 g (0.04 mol, 77percent yield) of brown solid compound methyl 3-chloro-lH-pyrrole-2-carboxylate.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Lee, Gay Hyung; Lim, Hee Jong; Cho, Hee Young; Park, Woo Kyu; Jung, Dae Young; (40 pag.)KR2017/74381; (2017); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem