Category: 879562-21-7

Product Details of 879562-21-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, is researched, Molecular C12H12ClNO3S, CAS is 879562-21-7, about Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. Author is Khan, Pasha M.; Correa, Ricardo G.; Divlianska, Daniela B.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Magnuson, Gavin; Brown, Brock; Suyama, Eigo; Yuan, Hongbin; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Vasile, Stefan; Smith, Layton H.; Diaz, Paul W.; Reed, John C.; Roth, Gregory P..

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.

Different reactions of this compound(1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride)Product Details of 879562-21-7 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shalygina, E. E.; Kobylinskii, D. V.; Ivanovskii, S. A.; Balakin, K. V.; Dorogov, M. V.; Toporova, T. A. researched the compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride( cas:879562-21-7 ).Application of 879562-21-7.They published the article 《Synthesis and properties of 1-acylindolinesulfonamides》 about this compound( cas:879562-21-7 ) in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya. Keywords: combinatorial library acylindolinesulfonamide preparation pharmacol potential. We’ll tell you more about this compound (cas:879562-21-7).

Title compounds I and II were prepared by N-acylation of indoline, bromination and chlorosulfonylation (or just chlorosulfonylation), and amidation. Several properties indicative of potential pharmacol. activities were determined

The article 《Synthesis and properties of 1-acylindolinesulfonamides》 also mentions many details about this compound(879562-21-7)Application of 879562-21-7, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Khan, Pasha M.; Correa, Ricardo G.; Divlianska, Daniela B.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Magnuson, Gavin; Brown, Brock; Suyama, Eigo; Yuan, Hongbin; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Vasile, Stefan; Smith, Layton H.; Diaz, Paul W.; Reed, John C.; Roth, Gregory P. published the article 《Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation》. Keywords: indoline tetrahydroisoquinoline aminobenzimidazole preparation; structure activity relationship pharmacokinetics NOD1 induced NFkappaB activation inhibitor.They researched the compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride( cas:879562-21-7 ).Application In Synthesis of 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:879562-21-7) here.

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.

As far as I know, this compound(879562-21-7)Application In Synthesis of 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, is researched, Molecular C12H12ClNO3S, CAS is 879562-21-7, about Synthesis and properties of 1-acylindolinesulfonamides.Formula: C12H12ClNO3S.

Title compounds I and II were prepared by N-acylation of indoline, bromination and chlorosulfonylation (or just chlorosulfonylation), and amidation. Several properties indicative of potential pharmacol. activities were determined

There are many compounds similar to this compound(879562-21-7)Formula: C12H12ClNO3S. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride(SMILESS: O=S(C1=CC2=C(N(C(C3CC3)=O)CC2)C=C1)(Cl)=O,cas:879562-21-7) is researched.Quality Control of Ethyl oxazole-5-carboxylate. The article 《Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:879562-21-7).

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.

Here is just a brief introduction to this compound(879562-21-7)Recommanded Product: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, more information about the compound(1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride) is in the article, you can click the link below.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Khan, Pasha M.; Correa, Ricardo G.; Divlianska, Daniela B.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Magnuson, Gavin; Brown, Brock; Suyama, Eigo; Yuan, Hongbin; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Vasile, Stefan; Smith, Layton H.; Diaz, Paul W.; Reed, John C.; Roth, Gregory P. researched the compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride( cas:879562-21-7 ).Formula: C12H12ClNO3S.They published the article 《Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation》 about this compound( cas:879562-21-7 ) in ACS Medicinal Chemistry Letters. Keywords: indoline tetrahydroisoquinoline aminobenzimidazole preparation; structure activity relationship pharmacokinetics NOD1 induced NFkappaB activation inhibitor. We’ll tell you more about this compound (cas:879562-21-7).

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.

If you want to learn more about this compound(1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride)Formula: C12H12ClNO3S, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(879562-21-7).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, is researched, Molecular C12H12ClNO3S, CAS is 879562-21-7, about Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.Safety of 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride.

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Mol. Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chem. synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacol. profiling of the 2-aminobenzimidazole lead, I, as a potent and selective inhibitor of NOD1-induced NF-κB activation.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Cyclopropanecarbonyl)indoline-5-sulfonyl chloride, is researched, Molecular C12H12ClNO3S, CAS is 879562-21-7, about Synthesis and properties of 1-acylindolinesulfonamides. Author is Shalygina, E. E.; Kobylinskii, D. V.; Ivanovskii, S. A.; Balakin, K. V.; Dorogov, M. V.; Toporova, T. A..

Title compounds I and II were prepared by N-acylation of indoline, bromination and chlorosulfonylation (or just chlorosulfonylation), and amidation. Several properties indicative of potential pharmacol. activities were determined

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem