Category: 96-54-8

Chemical Research Letters, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, in an article , author is Joksimovic, Nenad, once mentioned of 96-54-8, Category: pyrrolines.

Synthesis, characterization, anticancer evaluation and mechanisms of cytotoxic activity of novel 3-hydroxy-3-pyrrolin-2-ones bearing thenoyl fragment: DNA, BSA interactions and molecular docking study

In order to make a progress in discovering a new agents for chemotherapy with improved properties and bearing in mind the fact that substituted 3-hydroxy-3-pyrrolin-2-ones belong to a class of biologically active compounds, series of novel 1,5-diaryl-4-(2-thienylcarbonyl)-3-hydroxy-3-pyrrolin-2-ones were synthesized and characterized by spectral (UV-Vis, IR, NMR, ESI-MS), X-ray and elemental analysis. All compounds were examined for their cytotoxic effect on human cancer cell lines HeLa and MDA-MB 231 and normal fibroblasts (MRC-5). Four compounds, 3-hydroxy-1-(p-tolyl)-4-(2-thienylcarbonyl)-5-(4-chlorophenyl)-2,5-dihydro-1H-pyrrol-2-one (D10), 3-hydroxy-1-(3-nitrophenyl)-4-(2-thienylcarbonyl)-5-(4-(benzyloxy) phenyl)-2,5-dihydro-1H-pyrrol-2-one (D13), 3-hydroxy-1-(4-nitrophenyl)-4-(2-thienylcarbonyl)-5-(4-(benzyloxy) phenyl)-2,5-dihydro-1H-pyrrol-2-one (D14), and 3-hydroxy-1-(4-chlorophenyl)-4-(2-thienylcarbonyl)-5-(4-(benzyloxy) phenyl)-2,5-dihydro-1H-pyrrol-2-one (D15), that showed the highest cytotoxicity against malignant cells and the best selectivity towards normal cells were selected for further experiments. Results obtained by investigating mechanisms of cytotoxic activity suggest that selected 3-hydroxy-3-pyrrolin-2-one derivatives in HeLa cells induce apoptosis that is associated with S phase arrest (D13, D15, and D10) or unrelated to cell cycle distribution (D14). Additionally, to better understand their suitability for potential use as anticancer medicaments we studied the interactions between biomacromolecules (DNA or BSA) and D13 and D15. The results indicated that D13 and D15 have great affinity to displace EB from the EB-DNA complex through intercalation [K-sv = (3.7 +/- 0.1) and (3.4 +/- 0.1) x 10(3) M-1, respectively], an intercalative mode also confirmed through viscosity measurements. K-a values, obtained as result of fluorescence titration of BSA with D13 and D15 [K-a = (4.2 +/- 0.2) and (2.6 +/- 0.2) x 10(5) M, respectively], support the fact that a significant amount of the tested compounds could be transported and distributed through the cells. In addition, by DNA and BSA molecular docking study for D13, D14 and D15 is determined and predicted the binding mode and the interaction region.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.96-54-8, Name is 1-Methyl-1H-pyrrole, molecular formula is C5H7N, belongs to pyrrolines compound, is a common compound. In a patnet, author is Miyazaki, Hiroshi, once mentioned the new application about 96-54-8, Application In Synthesis of 1-Methyl-1H-pyrrole.

Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

We describe in this Letter a new synthetic method for pyrrolin-2-ones as potent plasminogen activator inhibitor-1 (PAI-1) inhibitors. Pyrrolin-2-one derivatives synthesized from N-2-oxoethylamides and aldehydes in aqueous NaOH by one-pot were evaluated for their PAI-1 inhibitory activity. Among these derivatives, compounds 16 and 18 were found to possess potent PAI-1 inhibitory activity (compound 16: IC(50): 0.69 mu M, compound 18: IC(50): 0.65 mu M). (C) 2009 Elsevier Ltd. All rights reserved.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New discoveries in chemical research and development in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is West, RR, once mentioned the application of 96-54-8, Name is 1-Methyl-1H-pyrrole, molecular formula is C5H7N, molecular weight is 81.1158, MDL number is MFCD00005345, category is pyrrolines. Now introduce a scientific discovery about this category, Safety of 1-Methyl-1H-pyrrole.

ZG-1494 alpha, a novel platelet-activating factor acetyltransferase inhibitor from Penicilium rubrum, isolation, structure elucidation and biological activity

A novel inhibitor of platelet-activating factor (PAF) acetyltransferase, an essential enzyme in the remodeling pathway of platelet-activating factor synthesis, was identified by a high throughput screen of natural product extracts of microbial origin. The compound, ZG-1494 alpha, was isolated from an ethyl acetate extract of a culture broth of Penicillium rubrum through bioassay guided fractionation. The structure of ZG-1494 alpha was determined by spectroscopic methods. A key feature of the structure, which is relatively rare among natural products, is the 5-hydroxy-3-pyrrolin-2-one moiety. A C-13-C-13 INADEQUATE was utilized to unambiguously determine the regiochemistry of this molecule.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 96-54-8 is helpful to your research. Safety of 1-Methyl-1H-pyrrole.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Electric Literature of 96-54-8, New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, belongs to pyrrolines compound. In a article, author is Pelkey, Erin T., introduce new discover of the category.

Reactions of 3-pyrrolin-2-ones

This review presents a systematic survey of the literature (through the end of 2017) that reports on the reactivity of 3-pyrrolin-2-ones. The discussion starts with site-specific reactivity (N, C2, C3, C4, and C5), followed by reactions across the C3-C4 pi-bond, and then transformations of 3-pyrrolin-2-ones to other heterocycles. Throughout the narrative, there is an attempt to show pertinent examples of 3-pyrrolin-2-ones being used as building blocks and intermediates leading to natural products and other complex heterocyclic targets. The review article contains a total of 601 references.

Electric Literature of 96-54-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 96-54-8.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New research progress on 96-54-8 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 96-54-8, Name is 1-Methyl-1H-pyrrole, molecular formula is C5H7N, belongs to pyrrolines compound, is a common compound. In a patnet, author is Thelen, Alexander E., once mentioned the new application about 96-54-8, SDS of cas: 96-54-8.

Detection of CH3C3N in Titan’s Atmosphere

Titan harbors a dense, organic-rich atmosphere primarily composed of N-2 and CH4, with lesser amounts of hydrocarbons and nitrogen-bearing species. As a result of high-sensitivity observations by the Atacama Large Millimeter/submillimeter Array (ALMA) in Band 6 (similar to 230-272 GHz), we obtained the first spectroscopic detection of CH3C3N (methylcyanoacetylene or cyanopropyne) in Titan’s atmosphere through the observation of seven transitions in the J = 64 -> 63 and J = 62 -> 61 rotational bands. The presence of CH3C3N on Titan was suggested by the Cassini Ion and Neutral Mass Spectrometer detection of its protonated form: C4H3NH+, but the atmospheric abundance of the associated (deprotonated) neutral product is not well constrained due to the lack of appropriate laboratory reaction data. Here, we derive the column density of CH3C3N to be (3.8-5.7).x.10(12) cm(-2) based on radiative transfer models sensitive to altitudes above 400 km Titan’s middle atmosphere. When compared with laboratory and photochemical model results, the detection of methylcyanoacetylene provides important constraints for the determination of the associated production pathways (such as those involving CN, CCN, and hydrocarbons), and reaction rate coefficients. These results also further demonstrate the importance of ALMA and (sub)millimeter spectroscopy for future investigations of Titan’s organic inventory and atmospheric chemistry, as CH3C3N marks the heaviest polar molecule detected spectroscopically in Titan’s atmosphere to date.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 96-54-8. SDS of cas: 96-54-8.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Reference of 96-54-8, New discoveries in chemical research and development in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, belongs to pyrrolines compound. In a article, author is Petroliagi, M, introduce new discover of the category.

Synthesis and NMR spectroscopic studies of optically active derivatives of gamma-aminobutenoic acids and 2-amino-pyrrolin-4-ones

An efficient method for the preparation of optically active derivatives of gamma -amino-butenoic acids and their cyclic derivatives, 2-amino-pyrrolin-4-ones, from alpha -amino acids is described. Partial racemization accompanies the formation of initial unsaturated gamma -amino- beta -hydroxy esters 5-8, as determined by chiral HPLC.

Reference of 96-54-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 96-54-8.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New Advances in Chemical Research in 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage , causing turnover rates to depend strongly on interfacial structure. 96-54-8, Name is 1-Methyl-1H-pyrrole, molecular formula is , belongs to pyrrolines compound. In a document, author is Rybalova, TV, Application In Synthesis of 1-Methyl-1H-pyrrole.

Investigation of conjugated dinitrones – Derivatives of pyrroline oxide

The molecular structure of three derivatives of bis(2-R-5,5-dimethyl-3-oxo-1-oxide pyrrolin-1-ylidene-3), where R = CH3 (5a), C6H5 (5b), C(CH3)(3) (5c), and of the complex of 5b with copper(II) hexafluoroacetylacetonate [Cu(hfac)(2) (5b)] was investigated by X-ray diffraction analysis in the framework of our studies of the possible tautomeric equilibrium conjugated dinitrone nitroxide biradical. The pyrroline rings of the molecules under analysis are planar (rms deviations of atoms are no more than 0.041 Angstrom), and the interplanar angles are 32.01(5), 42.84(9), and 51.45(7)degrees for 5a, 5b, and 5c, respectively. It is established that the bond lengths of the C(2)-C(3)=C(3a)-C(2a) fragment are equalized to C(2)-C(3) 1.42 and C(3)-C(3a) 1.40 Angstrom. The N–>O bond lengths of the nitrone group are within 1.250(4)-1.282(4) Angstrom [in Cu(hfac)2 (5b)]. The geometrical data obtained do not permit us to make an unambiguous choice between the tautomeric structures. The magnetic susceptibility measurements of the Cu(hfac)2 solid complex (5b) and the absence of paramagnetism in solid compounds 5 indicate that they are diamagnetic.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 96-54-8. The above is the message from the blog manager. Application In Synthesis of 1-Methyl-1H-pyrrole.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, belongs to pyrrolines compound. In a document, author is Chen, LJ, introduce the new discover, Category: pyrrolines.

Characterization of amino acid on glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan

Metabolic activation of the hepatocarcinogen furan yields metabolites that react covalently with proteins, cis-2-Butene-1,4-dial is a microsomal metabolite of furan, This reactive aldehyde is thought to be the toxic metabolite that is responsible for the carcinogenic activity of furan. In order to characterize the chemistry by which this unsaturated dialdehyde could alkylate proteins, the products formed upon reaction of cis-2-butene-1,4-dial with model nucleophiles in PH 7.4 buffer were investigated, N-alpha-Acetyl-L-cysteine (AcCys) reacts with cis-2-butene-1,4-dial to form N-substituted pyrrolin-2-one adducts. N-Acetyl-L-cysteine (AcCys) reacts rapidly with cis-2-butene-1,4-dial to form multiple uncharacterized products. The inclusion of AcLys in this reaction mixture yielded an N-substituted 3-(S-acetylcysteinyl)pyrrole adduct which Links the two amino acid residues. Related compounds were isolated when cis-2-butene-1,4-dial and glutathione (GSH) were combined. In this case, cis-2-butene-1,4-dial cross-linked two molecules of GSH resulting in either cyclic or acyclic adducts depending on the relative GSH concentration. Incubation of furan with rat liver microsomes in the presence of [glycine-2-H-3]GSH led to the formation of radioactive peaks that coeluted with synthetic standards for the bisgluthathione conjugates. These studies demonstrate that the reactive cis-2-butene-1,4-dial formed during the microsomal oxidation of furan reacts rapidly and completely with amino acid residues to farm pyrrole and pyrrolin-2-one derivatives. Therefore, this metabolite is a likely candidate for the activated furan derivative that binds to proteins. The ease with which cis-2-butene-1,4-dial cross-links amino acids suggests that pyrrole-thiol cross-links may be involved in the toxicity observed following furan exposure.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 96-54-8 is helpful to your research. Category: pyrrolines.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, belongs to pyrrolines compound. In a document, author is Arazo, Renato O., introduce the new discover, SDS of cas: 96-54-8.

Low-temperature catalytic conversion of alkaline sewage sludge bio-oil to biodiesel: Product characteristics and reaction mechanisms

Sewage sludge is a promising biomass alternative for the production of liquid biofuels. In this study, bio-oil derived from the fast pyrolysis of domestic sewage sludge was upgraded in a micro Robinson-Mahoney reactor at 4 MPa and 260 degrees C, and in the presence of hybridized Ni/HZSM-5 catalyst and ethanol. Fourier transform infrared and gas chromatography-mass spectrometry analyses were used to identify the functional groups and chemical components of raw and upgraded sewage sludge bio-oil. Results showed that catalytic upgrading reduced the relative content of acids, aldehydes, phenols, ketones, and nitrogenated compounds in the pyrolytic bio-oil. Thus, the main components of the upgraded bio-oil product included esters (48.59%), alkanes (10.12%), aromatics (9.38%), and alkenes (5.08%). Water and nitriles in the raw pyrolytic bio-oil together with in-situ-produced carbon oxides helped in the esterification of raw bio-oil. Reaction mechanisms such as nitrile hydrolysis, hydrogenation, and esterification were proposed to elucidate the conversion of the non-acidic pyrolytic bio-oil into ester-dominating upgraded bio-oil. Overall, upgrading sewage sludge pyrolytic oil is crucial to produce high-quality diesel-range biofuel. (C) 2020 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 96-54-8 is helpful to your research. SDS of cas: 96-54-8.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Synthetic Route of 96-54-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 96-54-8, Name is 1-Methyl-1H-pyrrole, SMILES is CN1C=CC=C1, belongs to pyrrolines compound. In a article, author is Pelkey, Erin T., introduce new discover of the category.

Reactions of 3-pyrrolin-2-ones

This review presents a systematic survey of the literature (through the end of 2017) that reports on the reactivity of 3-pyrrolin-2-ones. The discussion starts with site-specific reactivity (N, C2, C3, C4, and C5), followed by reactions across the C3-C4 pi-bond, and then transformations of 3-pyrrolin-2-ones to other heterocycles. Throughout the narrative, there is an attempt to show pertinent examples of 3-pyrrolin-2-ones being used as building blocks and intermediates leading to natural products and other complex heterocyclic targets. The review article contains a total of 601 references.

Synthetic Route of 96-54-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 96-54-8.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem