Category: pyrrolines

Related Products of 58081-05-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of a new cerebroside isolated from Typhonium giganteum Engl.

The stereoselective synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4, 8-sphingadienine, α-hydroxy acid and a saccharide head. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a SN2 type reaction. α-Hydroxy acid was prepared from (R)-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from L-ascorbic acid.

The article 《Synthesis of a new cerebroside isolated from Typhonium giganteum Engl》 also mentions many details about this compound(58081-05-3)Related Products of 58081-05-3, you can pay attention to it, because details determine success or failure

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Taming carbohydrate complexity: a facile, high-yield route to chiral 2,3-dihydroxybutanoic acids and 4-hydroxytetrahydrofuran-2-ones with very high optical purity from pentose sugars.Application of 58081-05-3.

(S)-3,4-Dihydroxybutanoic acid and its γ-lactone [(S)-4-hydroxytetrahydrofuran-2-one] are important four-carbon synthons obtainable from some substituted D-hexose sugars and from L-malic acid. Until now there has been no easy route to the R-isomers because of the rarity both of suitably substituted L-hexose sugars and D-malic acid. Here we describe a method for preparing both enantiomeric forms of the free acids and their corresponding γ-lactones from pentose sugars.

The article 《Taming carbohydrate complexity: a facile, high-yield route to chiral 2,3-dihydroxybutanoic acids and 4-hydroxytetrahydrofuran-2-ones with very high optical purity from pentose sugars》 also mentions many details about this compound(58081-05-3)Application of 58081-05-3, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-5-iodo-3-methylpyridine, is researched, Molecular C6H5ClIN, CAS is 59782-89-7, about Methyl, Trifluoromethyl, and Methoxycarbonyl-Introduction to the Fifth Position on the Pyridine Ring of Chloronicotinyl Insecticide Imidacloprid, the main research direction is Imidacloprid derivative methyl trifluoromethyl methoxycarbonyl preparation; chloro nicotine Imidacloprid methyl trifluoromethyl methoxycarbonyl preparation.Recommanded Product: 59782-89-7.

Imidacloprid is the first (chloro)nicotine insecticide and is currently the largest-selling insecticide worldwide. As a project to find its variants of different insecticidal spectra, derivatives substituted with Me, trifluoromethyl, and methoxycarbonyl at the fifth position on the pyridine ring of imidacloprid were prepared

The article 《Methyl, Trifluoromethyl, and Methoxycarbonyl-Introduction to the Fifth Position on the Pyridine Ring of Chloronicotinyl Insecticide Imidacloprid》 also mentions many details about this compound(59782-89-7)Recommanded Product: 59782-89-7, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4045-24-3, is researched, SMILESS is COC1CCNCC1, Molecular C6H13NOJournal, Article, Organic Letters called Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation, Author is An, Yang; Li, Yuke; Zhang, Xiao-Yan; Zhang, Zhe; Gou, Xue-Ya; Ding, Ya-Nan; Li, Qiao; Liang, Yong-Min, the main research direction is amino fused bicyclic compound preparation regioselective; iodoarene benzoyloxyamine norbornadiene Catellani reaction amination cyclization palladium catalyst.Related Products of 4045-24-3.

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2+3] or [2+4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates ortho-substituents that avoid a second C-H palladation. The scope of substrates was broad, o-methyl-substituted iodoarenes R-2-CH3-C6H3I (R = H, 4-F, 3-Me, 4-Cl, etc.), 3-iodo-4-methyl-pyridine were applied to the reaction smoothly, and o-phenyl-substituted iodoarenes 2-I-C6H4-(4-R1C6H4-) (R1 = H, Me, Ph, F, etc.), 1-(2-iodo-phenyl)-naphthalene can also be obtained by this method. In terms of mechanism, d. functional theory calculations proved the sequence of the key five-membered aryl-norbornene-palladacycle intermediate formation and C(sp3 or sp2)-H activation.

The article 《Palladium-Catalyzed C-H Amination/[2+3] or [2+4] Cyclization via C(sp3 or sp2)-H Activation》 also mentions many details about this compound(4045-24-3)Related Products of 4045-24-3, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 58081-05-3, is researched, SMILESS is O=C1OC[C@H](O)C1, Molecular C4H6O3Journal, Tetrahedron Letters called Total syntheses of oscillatoxin D and 30-methyloscillatoxin D, Author is Toshima, Hiroaki; Goto, Takashi; Ichihara, Akitami, the main research direction is oscillatoxin methyloscillatoxin D total synthesis.Product Details of 58081-05-3.

The first total syntheses of oscillatoxin D and 30-methyloscillatoxin D have been accomplished. The construction of the spiroether has been achieved by intramol. Michael-type addition as a key step based on a possible biomimetic pathway.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Zhang, Jian; Kovac, Pavol published an article about the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3,SMILESS:O=C1OC[C@H](O)C1 ).Recommanded Product: 58081-05-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:58081-05-3) through the article.

The following analogs of the title determinant, Me 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-methyl-α-D-mannopyranoside, have been prepared: Me 3,4,6-trideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-methyl-α-D-mannopyranoside, Me 4,6-dideoxy-4-(4-hydroxybutyramido)-2-O-methyl-α-D-mannopyranoside, Me 4,6-dideoxy-4-(3,4-dideoxy-L-glycero-tetronamido)-2-O-methyl-α-D-mannopyranoside, Me 1 4,6-dideoxy-4-(3-deoxy-D-glycero-tetronamido)-2-O-methyl-α-D-mannopyranoside, Me 4,6-dideoxy-4-(2-deoxy-L-glycero-tetronamido)-2-O-methyl-α-D-mannopyranoside, Me 4-acetamido–4,6-dideoxy-2-O-methyl-α-D-mannopyranoside, Me 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-ethyl-α-D-mannopyranoside, and Me 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-propyl-α-D-mannopyranoside.

The article 《Synthesis of ligands related to the Vibrio cholerae O-specific antigen. 15. Synthesis of some analogs of the methyl α-glycoside of the presumed antigenic determinant of the O-specific polysaccharide of Vibrio cholerae O:1, serotype Ogawa》 also mentions many details about this compound(58081-05-3)Recommanded Product: 58081-05-3, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Han, Dongyang; Li, Sasa; Xia, Siqi; Su, Mincong; Jin, Jian researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Recommanded Product: 4045-24-3.They published the article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 about this compound( cas:4045-24-3 ) in Chemistry – A European Journal. Keywords: aryl halide amine amination coupling nickel catalyst regioselective chemoselective; C−N coupling; amination; anilines; aryl halides; nickel catalysis. We’ll tell you more about this compound (cas:4045-24-3).

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodol. features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides RX (R = 4-methanesulfonylphenyl, 3-cyanopyridin-2-yl, 1,3-benzoxazol-2-yl, etc.; X = Br, Cl) were coupled successfully with primary and secondary alkyl amines and anilines such as cyclohexanamine, pyrrolidine, 4-methylaniline, etc. in good to excellent yields RR1 [R1 = cyclohexylaminyl, pyrrolidin-1-yl, (4-methylphenyl)aminyl, etc.]. Similarly, benzophenone imine gave the corresponding N-arylation product N-(4-(methylsulfonyl)phenyl)-1,1-diphenylmethanimine in an excellent yield.

The article 《Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive》 also mentions many details about this compound(4045-24-3)Recommanded Product: 4045-24-3, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Electric Literature of C4H6O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of 11-C-20-C segment of leukotriene B4 and migration of silyl protecting group. Author is Wang, Yanfang; Li, Jincui; Wu, Yulin.

A new synthesis of 11-C-20-C segment of leukotriene B4, 2(R)-hydroxydec-4(Z)-enal derivatives I (R = SiPh2CMe3, SiMe2CMe3, CPh3) using ascorbic acid as chiron is described. A partial or full migration of silyl protecting group from a secondary hydroxy group to a vicinal primary one is discovered in the Wittig reaction of hemiacetals II (R1 = SiPh2CMe3, SiMe2CMe3) with Me(CH2)5P+Ph3Br-.

The article 《Synthesis of 11-C-20-C segment of leukotriene B4 and migration of silyl protecting group》 also mentions many details about this compound(58081-05-3)Electric Literature of C4H6O3, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2-Methylbenzo[d]oxazol-5-yl)methanol, is researched, Molecular C9H9NO2, CAS is 136663-38-2, about Design, synthesis and antimicrobial activity of novel 2-substituted benzoxazole derivatives.SDS of cas: 136663-38-2.

In the current research work, the title compounds were synthesized from Me 2-substituted benzoxazole-5-carboxylate by refluxing with methanol and THF (1 : 1) in presence of NaBH4, which afforded (2-substituted benzoxazol-5-yl)methanol, on partial oxidation with PCC furnished 2-substituted benzoxazole-5-carbaldehyde, on treatment with appropriate carbonyl compounds monoethyl malonate, Et acetoacetate or malonic acid yielded the corresponding α,β-unsaturated derivatives of 2-substituted benzoxazoles like, Et 3-(2-substituted benzoxazol-5-yl)acrylate, 4-(2-substituted benzoxazol-5-yl)but-3-en-2-one and 3-(2-substituted benzoxazol-5-yl)acrylic acid. The identification and characterization of all the synthesized compounds were confirmed by elemental anal., m.p., thin layer chromatog., FTIR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biol. activities and pharmacol. importance associated with benzoxazole derivatives, some of the derivatives of benzoxazole containing heterocyclic ring were prepared and their bio-potential were evaluated.

The article 《Design, synthesis and antimicrobial activity of novel 2-substituted benzoxazole derivatives》 also mentions many details about this compound(136663-38-2)SDS of cas: 136663-38-2, you can pay attention to it, because details determine success or failure

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer, published in 2021-01-15, which mentions a compound: 4045-24-3, mainly applied to pyrimidine human colorectal cancer anticancer apoptosis; AMP-Activated protein kinase (AMPK); Colorectal cancer; NUAK; WZ4003 derivatives, COA of Formula: C6H13NO.

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound I, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, I suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation.

The article 《Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer》 also mentions many details about this compound(4045-24-3)COA of Formula: C6H13NO, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem