Tag: 1122-10-7

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound (5) was synthesized by substituting bromine of dibromomaleimide (4), and 10% KOH (200 ml) was added to compound (5) (0.71 g, 2 mmol) and refluxed for 30 minutes. Next, the reaction was cooled and acidified with 2N HCl to collect red precipitates. The resulting precipitate was extracted with ethyl acetate (2 x 100 mL) and evaporated in vacuo to give a crudeproduct. The crude product was then chromatographed on silica gel (EtOAc / hexane = 3: 1) 667 mg of To obtain bisindole maleic anhydride (6) in a red powder state (yield: 95%).

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chungnam National University Industry-Academia Collaboration Foundation; Son, Yeong-a; (10 pag.)KR2016/11409; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1).

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

2,3-Dibromomaleimide(2.55 g, 10.0 mmol)Placed in 100mL three-necked flask,Was dissolved in 30 mL of dry DMF,Nitrogen protection,Down to 0 ,Sodium hydride was added in two portions(480 mg, 12 mmol, 60% by mass dispersed in paraffin).After 1 h, 10 mL of dry DMF was addedDissolved chloromethyl benzyl methyl ether(2.08 mL, 15 mmol),The reaction was allowed to proceed to room temperature for 2 h.After falling to 0 ,The reaction was quenched by the addition of 20 mL of saturated ammonium chloride solution,Ethyl acetate extraction,The organic phase was dried over anhydrous sodium sulfate and concentrated,Pressurized column chromatography Petroleum ether: ethyl acetate = 50: 1 (v / v)To give 3.55 g of the compound N-benzyloxymethyl-2,3-dibromomaleimide,Yield 94%.A magnesium wire (432 mg, 18.0 mmol)Was placed in a 100 mL dry three-necked flask,4 mL of dry tetrahydrofuran was added,Argon replacement,After the introduction of anhydrous bromoethane(1.35 mL, 18.0 mmol),Reaction at room temperature for 15min then rose to 40 reaction 30min.The indole was introduced with a catheter(2.11 g, 18.0 mmol),Reaction 1h.N-benzyloxymethyl-2,3-dibromomaleimide (3.29 g, 8.9 mmol) was added,Reaction at room temperature for 4h.The reaction was quenched by the addition of 20 mL of saturated ammonium chloride solution,Ethyl acetate extraction,The organic phase was dried over anhydrous sodium sulfate and concentrated,Pressure column chromatography,Petroleum ether: ethyl acetate = 4: 1 (v / v)To give 3.46 g of compound 185a,Yield 94%.

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; Ocean University of China; The Key Laboratory of Chemistry Natural Products of Guizhou Province and Chinese Academy; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; Hao, Jiejie; (142 pag.)CN106146475; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem