With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1193-54-0,3,4-Dichloro-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
A solution of 6.64 g [0.04 mol] of dichloromaleimide (VI-2) in 40 ml of methanol is introduced at 65 C. and, over the course of about 10 minutes, a solution, likewise heated at 65 C., of 13.89 g [0.056 mol] of sodium thiosulfate pentahydrate in 40 ml of water is added dropwise. After the end of the addition, the mixture is stirred for hour more at 65 C. Thereafter the reaction mixture is cooled to 15 C., 10 and of water are added, and it is stirred for 15 minutes. Thereafter the solid is isolated by filtration with suction, washed with 30 ml of water and then 15 ml of MODEL and dried. This gives 3.6 g of dark-green solid, which according to HPLC analysis is composed to an extent of 99.6 area-% of the compound (I-2), corresponding to a yield of 71% of theory.
As the paragraph descriping shows that 1193-54-0 is playing an increasingly important role.
Reference£º
Patent; Bayer CropScience AG; US2011/257411; (2011); A1;,
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