Tag: 5264-35-7

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 2-(Dimethylaminoethylamino-1-pyrroline Into a solution of 4.4 gm. (0.05 mole) of N,N-dimethylethylene diamine in 15 ml. of methanol with cooling is added 3.6 gm. (0.1 mole) of hydrogen chloride gas and then at room temperature is added 5.6 gm. (0.05 mole) of 88percent 2-methoxy-1-pyrroline and let stir at ambient temperature for 221/2 hours. Removed the methanol, dissolved the residue in water, neutralized with sodium hydroxide and extracted with methylene chloride, dried and evaporated affording 8.0 gm. of 2-(dimethylaminoethylamino)-1-pyrroline.

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; Merck & Co., Inc.; US4241072; (1980); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B) 1-(2-oxo-2-(4-(trifluoromethoxy)phenyl)ethyl)pyrrolidin-2-one A mixture of 5-methoxy-3,4-dihydro-2H-pyrrole (5.60 g) and 2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone (3.00 g) in N,N-dimethylformamide (20 mL) was stirred at 50-60¡ãC for 5 hr, water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the title compound (2.32 g). 1H NMR (400 MHz, CDCl3) delta 2.01-2.15 (2H, m), 2.48 (2H, t, J = 8.0 Hz), 3.50 (2H, t, J = 7.2 Hz), 4.70 (2H, s), 7.31 (2H, d, J = 8.0 Hz), 8.03 (2H, d, J = 8.8 Hz).

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; MIKAMI, Satoshi; NAKAMURA, Shinji; ASHIZAWA, Tomoko; SASAKI, Shigekazu; TANIGUCHI, Takahiko; NOMURA, Izumi; KAWASAKI, Masanori; EP2848618; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[4-(piperidin-4-yloxy)-3-trifluoromethylphenyl]sulfamoylacetate dihydrochloride (800 mg) obtained in example 77(a) in ethanol (20 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole (370 mg), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (0.87 ml) at room temperature, and the resulting mixture was stirred at room temperature overnight.. Because of the slow progress of the reaction, 5-methoxy-3,4-dihydro-2H-pyrrole (120 mg) and triethylamine (0.26 ml) were furthermore added successively and the resulting mixture was stirred at room temperature for 4 hours.. After stirring, to the reaction mixture was added a 4N solution of hydrogen chloride in dioxane and the resulting mixture was evaporated in vacuo.. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 26 percent acetonitrile/water).. The amorphous solid obtained was dissolved in 1N hydrochloric acid, and the resulting mixture was evaporated to dryness in vacuo.. The residue obtained was dissolved in water and then lyophilized to afford the title compound (622 mg, yield: 70 percent) as a colorless amorphous solid. 1H NMR (400MHz, DMSO-d6) delta ppm: 1.22 (3H, t, J=7.0), 1.82 (2H, m), 2.00-2.15 (4H, m), 2.97 (2H, t, J=8.0), 3.53-3.64 (4H, m), 3.72 (2H, m), 4.19 (2H, q, J=7.0), 4.45 (2H, s), 4.50 (2H, d, J=6.0), 4.96 (1H, m), 6.46 (1H, dt, J=16.0, 6.0), 6.58 (1H, d, J=16.0), 7.44 (1H, d, J=10.0), 7.55 (1H, t, J=8.0), 7.67-7.75 (4H, m), 7.90 (1H, s); IR (KBr, cm-1): 1739, 1672, 1353, 1144.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem