Tag: 7544-75-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.

Prepare 2-iminopyrrolidine hydrochloride (6. 98 g, 57.8 mmol) according to Callahan, et al., J. Med. Chem. 2002,45, 999-1001) and combine 2-bromoacetophenone (3.8 g, 19.3 mmol) with Na2CO3 (8.2 g, 77.2 mmol) in dry DMF (25 [ML)] and heat at [80C] for 18 hours. Then, cool the mixture to room temperature, add water (60 mL), and extract with EtOAc (3 x 100 mL). Concentrate the combined organic layers in vacuo, dilute the residue with ether (100 mL), and wash with cooled water (3 x 80 mL). Concentrate the organic layer in vacuo to give a white solid, 3.2 g, 89 [%] yield. MS [(ES+)] : [IIZLZ] = 185. 1 [(M+H) +], 7544-75-4

7544-75-4 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride 12778905, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/14900; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

7544-75-4, 3,4-Dihydro-2H-pyrrol-5-amine hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) A DMA (35 ml) suspension containing Compound 1 (5.57 g, 28 mmol), Compound 2 (10 g, 83 mmol) and sodium carbonate (12 g, 113 mmol) was stirred at 80 C. for 15 hours under argon atmosphere. After cooling by allowing to stand, the reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over anhydrous sodium sulfate, and then, concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (hexane:ethyl acetate=3:2) to give Compound 3 (2.02 g, 11 mmol, 39%) as a solid.

As the paragraph descriping shows that 7544-75-4 is playing an increasingly important role.

Reference£º
Patent; Kusama, Mari; Watanabe, Tatsuya; Hosaka, Toshihiro; Kubota, Yuko; US2008/9506; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem