Tag: M.W:200-300

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

17057-04-4, As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 2.5 g of 3,4-dibromo-1H-pyffole-2,5-dione (10 mmol) and 1 g of NMM in 60 mL of THF, MeOCOC1 (10 mmol, 940 mg in 10 ml DCM) was added dropwise, stuffed for 20 mm, then the reaction solution was diluted with 6o mL of DCM, washed 3 time by water, the organic phase was stirred by sodium sulfate anhydrous, concentrated, 2.65g of methyl 3,4-dibromo-2,5-dioxo-2H-pyrrole-1(5H)-carboxylate was obtained. To 311mg, 1 mmol of this compound, 2-(2-azidoethoxy)ethanamine (130 mg, 1 mmol) and 5 mL DCM was added, TLC shown the reaction finished in 20 mm, then extracted by DCM and brine, washed by NH4C1 solution, dried on sodium sulfate anhydrous, and then concentrated for column purification, flashed by 2:1 hexane and ethyl ethylate, 230 mg of 1-(2-(2-azidoethoxy)ethyl)-3,4-dibromo-1H-pyffole-2,5-dione obtained. 1HNMR: 3.32 ppm (t, J = 5.0 Hz, 1H), 3.40 ppm (t, J = 5.0Hz, 1H), 3.50 ppm (q, J =5.0 Hz, 1H), 3.62 ppm (t, J = 5.0 Hz, 1H), 3.63-3.69 ppm (m, 3H),3.84 ppm (t, J = 5 hz, 1H). Fw: 365.9, C8H8Br2N4O3 Mass Peaks (1:2:1): 366.9, 368.9,370.9.

1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SORRENTO THERAPEUTICS, INC.; FU, Yanwen; KAUFMANN, Gunnar, F.; JONES, Bryan; TOUGHIRI, Raheleh; (82 pag.)WO2015/175357; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,4-dibromo-N-methyl ester maleimide was synthetized from the corresponding 3,4-dibromomaleimide by adapting the procedure disclosed by Castaeda et al. in Tetrahedron Lett. 2013, 54, 3493-3495.3,4-dibromomaleimide (5 g, 19.92 mmol) was dissolved in THE (175 ml). N-methylmorpholine (2.16 ml, 19.92 mmol) and methyl chloroformate (1.51 ml, 19.92 mmol) were added at room temperature under argon. The reaction mixture was stirred at room temperature under argon for 20 mm, then diluted with DCM (200 ml). The organic layer was washed with water (200 ml), dried over MgSO4, concentrated and lyophilized to yield 6.15 g (100%) of product.[00252] 1H NMR (500 MHz, CDCI3): 5= 4.01 (5, 3H). 130 NMR (126 MHz, CDCI3): 5= 159.23, 146.91, 131.41, 54.79., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; HEIDELBERG PHARMA RESEARCH GMBH; GALLO, Francesca; KORSAK, Barbara; MUELLER, Christoph; HECHLER, Thorsten; PAHL, Andreas; KULKE, Michael; SIMON, Werner; LUTZ, Christian; (163 pag.)WO2019/57964; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2,3-dibromomaleimide23 (1.0 mmol) in CH2Cl2 (20ml) Et3N (2.0mmol) and thiol (2.1mmol) were added under argon atmosphere and stirred for 3 h at room temperature. The reaction mixture was evaporated,and the crude product was purified by flash chromatography to give the desired compound.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of maleimide (2.0 g, 20.6 minol) in CHCI3 (20 mL) was added a solution of Br2(1.1 mL, 21.33 minol) in CHCI3 (15 mL). The mixture was heated to reflux for 2 h and thencooled to rt. The precipitate formed was collected by Buchner filtration (Whatman number5 paper) and washed with cold CHCI3 (2 x 50 mL) to afford the crude dibromo-maleimide asa pale yellow powder that was used without further purification. Crude dibromo-maleimidewas dissolved in anhydrous THF (50 mL) and cooled to 0 C. A solution of anhydrous NEt3(2.9 mL) in anhydrous THF (10 mL) was then added over 5 mins and the resulting pale pinksuspension stirred at 0 C for 2 h. Without warming, the suspension was filtered and thefiltrate concentrated in vacuo to afford the title compound 24 (2.30 g, 63%) as a light yellow solid. 1H NMR (400 MHz, CDCI3) oe 6.89 (1H, s, 5-H), 7.68 (1H, br s, 2-H); 13C NMR (100 MHz, CDCI3) oe 132.2, 132.8, 164.8, 167.8. The 1H and 13C NMR data obtained was in agreement with that reported from literature.20

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SAMMUT, Ivan Andrew; HARRISON, Joanne Clare; HEWITT, Russell James; READ, Morgayn Iona; STANLEY, Nathan John; WOODS, Laura Molly; KUEH, Jui Thiang Brian; JAY-SMITH, Morgan; SMITH, Robin Andrew James; GILES, Gregory; LARSEN, Lesley; RENNISON, David; BRIMBLE, Margaret Anne; LARSEN, David Samuel; (209 pag.)WO2017/95237; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: Synthetic routes of the target compound, pyrene-bisindolylmaleimide (PBM), are outlinedin Scheme 1. The synthesis of PBMstarted from dibromomaleimide (1), whichwas coupledwith two equivalents of 2-methylindole-MgBr and yielded bis-2-methylindolylmaleimide(BM) [10, 11]. Followed by the hydrolysis of 2 in KOH aqueous solution, bis-2-methylindolylmaleic acid anhydride was obtained with the nitrogen atom replaced byoxygen atom [12]. Subsequent imidization of bis-2-methyindolemaleic anhydride with1-aminopyrene yielded the target compound PBM. Bis-2-methylindolylmaleic acid anhydride (50 mg, 0.14 mmol) and 1-aminopyrene(35 mg, 0.16 mmol) dissolved in 2-methoxyethanol (25 mL). Three drops of triethylaminewas added to the solution. The mixture was heated to reflux for about 24 h. The reactionprocess was monitored by TLC. After the bis-2-methylindolylmaleic acid anhydride wasdisappeared. The reactionmixture was cool to ambient temperature and poured to water (25mL). The mixture was extracted with ethyl acetate (25 mL¡Á3). The collected organic phasewas dried over MgSO4. After filtration, the solvent was evaporated in vacuum. The crudeproduct was purified by silica gel column chromatography with ethyl acetate/petroleumether (1:2) as the eluant, affording dark red solid of PBM (61 mg, yield, 78%)., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Li, Xiaochuan; Son, Young-A; Molecular Crystals and Liquid Crystals; vol. 601; 1; (2014); p. 182 – 189;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

1122-10-7, Somatostatin is peptide hormone which is known to exist ina form in which two cysteine residues within the molecule areattached via a disulfide bridge.1 mg of lyophilised somatostatin (Sigma-Aldrich) was resolubilised in 2 ml of 50mM NaHPO4, pH 6.2, 40% MeCN, 2.5% DMF. 500 jil were transferred to a Eppendorf reactiontube and diluted in the same buffer to a final concentration of0.25 mg/ml (152.6 jiM). 2.0 equivalents of TCEP (lOOx stock solution in 50 mM NaHPO4, pH 6.2, 40% MeCN) were added and the reaction incubated for 1 hour at ambient temperature. After reduction of the di sulfide bond 1.4 equivalentsof 2,3-dibromomaleimide (Sigma-Aldrich, lOOx stock solution in 50 mM NaHPO4, pH 6.2, 40% MeCN, 2.5% DMF)were added, the solution gently mixed and incubated for afurther 12 h at 4 C.Maleimide-bridged somatostatin was detected by EC-ESI65 MS (ES/ES). Controls included untreated peptide andsomatostatin treated with 2,3-dibromomaleimide or TCEPonly. Complete reduction was detected by the reaction of TCEP-treated peptide with maleimide (Sigma-Aldrich, lOOx stock solution in 50 mM NaRPO, pH 6.2, 40% MeCN, 2.5% DMF).Untreated somatostatin: [ES+]i638.04 (m/z 1), 819.82 (mlz 2), 546.95 (mlz 3). Maleimide-bridged somatostatin:[ES+] 1734.14 Da (mlz 1), 867.40 Da (mlz 2), 578.73 (mlz 3).

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; UCL Business Plc; Smith, Mark; Caddick, Stephen; Baker, James; Chudasama, Vijay; (80 pag.)US9295729; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2,3-dibromomaleimide23 (1.0 mmol) in CH2Cl2 (20ml) Et3N (2.0mmol) and thiol (2.1mmol) were added under argon atmosphere and stirred for 3 h at room temperature. The reaction mixture was evaporated,and the crude product was purified by flash chromatography to give the desired compound.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

MeVal-Val-Dil-Dap-Phe-OtBu (compound 1, 35 mg, 0.044 mmol) was suspended in DMF (0.250 mL). 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid (11 mg, 0.049 mmol) and HATU (17 mg, 0.044 mmol) were added followedby DIEA (0.031 mL, 0.17 mmol). This reaction mixture was allowed to stir for 2.0 hr. HPLC analysis indicated completeconsumption of starting compound 1.[0565] Product was isolated via preparatory RP-HPLC, using a Phenomenex C12 Synergi Max-RP 80A Column (250x 21.20 mm). Eluent: linear gradient 10% to 80% MeCN/0.05% TFA (aq) over 8 minutes, then isocratic 80% MeCN/0.05%TFA (aq) for an additional 12 minutes. A total of 20 mg of pure product (14) was isolated (0.02 mmol, 46% yield). ESMSm/z 987.85 [M+H]+; 1019.41 [M+Na]+; 985.54 [M-H]-., 17057-04-4

As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

Reference£º
Patent; Seattle Genetics, Inc.; Doronina, Svetlana O.; Senter, Peter D.; Toki, Brian E.; Ebens, Allen J.; Kline, Toni Beth; Polakis, Paul; Sliwkowski, Mark X.; Spencer, Susan D.; EP2486933; (2015); B1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

In a 50 mL two-necked flask,NaH (30 mg, 0.75 mmol, mass fraction 60%,Dispersion in paraffin) with 5mL DMF suspension stirring,Dropwise at -5 5mLDMF dissolved in 2,3-dibromo maleimide(127.5 mg, 0.5 mmol),After reaction at low temperature for 30 min,Methyl iodide (47 [mu] L, 0.75 mmol) was added dropwise,Low temperature reaction 30min,The reaction was quenched by dropwise addition of saturated NH4Cl solution,CH2Cl2 extraction,The organic layer was evaporated to dryness,Silica gel column chromatography,Petroleum ether: ethyl acetate = 30: 1 (v / v) to give white crystals(82a)Yield 69%., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; Ocean University of China; The Key Laboratory of Chemistry Natural Products of Guizhou Province and Chinese Academy; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; Hao, Jiejie; (142 pag.)CN106146475; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem